Isoxilan

Isoxilan

isoxsuprine

Manufacturer:

BIOFEMME, Inc

Distributor:

BIOFEMME, Inc
Concise Prescribing Info
Contents
Isoxsuprine HCl
Indications/Uses
Uterine hypermotility disorders eg, threatened abortion & uncomplicated premature labor. Adjunct therapy in the treatment of peripheral vascular disease eg, arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) & Raynaud's disease. Relief of symptoms associated w/ cerebrovascular insufficiency.
Dosage/Direction for Use
Uterine hypermotility Oral 20 mg tid-qid when uterine contractions have ceased for at least 12 hr w/ parenteral isoxsuprine. IV Infusion Initially, 100 mg in 500 mL infusion fluid w/ starting infusion rate of 0.5 mL/min (10 drops/min). Increase infusion rate in increments of 10 drops/min at 10 min interval. IM inj 10 mg every 3 hr for 24 hr then 4-6 hr for 48 hr. Circulatory disturbances Oral 20 mg tid-qid. Inj 5-10 mg IM tid.
Administration
May be taken with or without food: May be taken w/ meals, milk or antacids to minimise GI discomfort.
Contraindications
Following recent arterial hemorrhage, known heart disease & severe anemia. Hypotension, tachycardia, premature detachment of the placenta, immediately postpartum & premature labor if there is infection.
Special Precautions
Discontinue if rash develops. To avoid pulmonary edema in women treated for premature labor, monitor for state of hydration, cardiac & resp function. Keep fluid infusions vol to the min. For infusion, hypotonic dextrose is preferred over isotonic saline soln. If signs of pulmonary edema develop, discontinue immediately & institute diuretic therapy. Childn.
Adverse Reactions
Trembling, nervousness, weakness, dizziness, flushing, transient palpitation, tachycardia, chest pain, hypotension, abdominal distress, nausea, vomiting, intestinal distention, & severe rash.
Drug Interactions
May cause severe hypotension w/ other vasodilators & antihypertensives.
ATC Classification
C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.
Presentation/Packing
Form
Isoxilan tab 10 mg
Packing/Price
100's (P22.5/pack)
Form
Isoxilan inj 5 mg/mL
Packing/Price
2 mL x 5 × 1's (P181.75/box)
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