Keppra

Keppra

levetiracetam

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig
Concise Prescribing Info
Contents
Levetiracetam
Indications/Uses
Monotherapy in the treatment of partial onset seizures w/ or w/o secondary generalization in adults & adolescents ≥16 yr w/ newly diagnosed epilepsy. Adjunctive therapy in the treatment of partial onset seizures w/ or w/o secondary generalization in adults, adolescents & childn ≥4 yr w/ epilepsy; myoclonic seizures in adults & adolescents ≥12 yr w/ juvenile myoclonic epilepsy & primary generalized tonic-clonic seizures in adults & childn ≥4 yr w/ idiopathic generalized epilepsy.
Dosage/Direction for Use
Monotherapy Adult & adolescent from 16 yr Initially 250 mg bid, increased to 500 mg bid after 2 wk. May be further increased by 250 mg bid every 2 wk. Max: 1,500 mg bid. Add-on therapy Adult (≥18 yr) & adolescent (12-17 yr) ≥50 kg Initially 500 mg bid, may be increased up to 1,500 mg bid. Dose may be increase or decrease to 500 mg bid every 2-4 wk. Childn & adolescent ≥50 kg Adult dose, 4-17 yr <50 kg Initially 10 mg/kg bid, may be increased up to 30 mg/kg bid. Dose increment/decrement should not be >10 mg/kg bid every 2 wk. Oral soln Childn ≤20 kg Initially 100 mg/mL.
Administration
May be taken with or without food: Oral soln: May be taken directly or diluted in a glass of water.
Contraindications
Hypersensitivity to levetiracetam or other pyrrolidone derivatives.
Special Precautions
Avoid abrupt w/drawal. Monitor for signs of depression &/or suicidal ideation & behaviors. Renal & severe hepatic impairment. Contains sunset yellow lake (tab) & methyl & propyl parahydroxybenzoate (oral soln) which may cause allergic reactions. May impair ability to drive or operate machinery. Pregnancy & lactation. Infants <1 yr w/ epilepsy. Childn <6 yr (tab), <4 yr & infants (infusion conc). Elderly. Oral soln: Rare hereditary problems of fructose intolerance (due to maltitol content) & may cause headache, stomach upset & diarrhea (due to glycerol content). Soln for infusion: Patients on controlled Na diet.
Adverse Reactions
Nasopharyngitis, somnolence, headache, anorexia, depression, hostility/aggression, anxiety, insomnia, nervousness/irritability, convulsion, balance disorder, dizziness, lethargy, tremor, vertigo, cough, abdominal pain, diarrhea, dyspepsia, vomiting, nausea, rash, asthenia/fatigue.
Drug Interactions
Higher clearance w/ enzyme-inducing antiepileptic drugs (in childn). Slightly reduced absorption w/ food. Decreases methotrexate clearance.
MIMS Class
Anticonvulsants
ATC Classification
N03AX14 - levetiracetam ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Keppra FC tab 1000 mg
Packing/Price
60's
Form
Keppra FC tab 250 mg
Packing/Price
60's
Form
Keppra FC tab 500 mg
Packing/Price
60's
Form
Keppra infusion conc 500 mg/5 mL
Packing/Price
(vial) 5 mL x 10 × 1's; (vial) 5 mL x 5 × 1's
Form
Keppra oral soln 100 mg/mL
Packing/Price
300 mL x 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in