Losarite

Losarite

losartan + hydrochlorothiazide

Manufacturer:

RiteMED

Distributor:

United Lab
Concise Prescribing Info
Contents
Per 50 mg/12.5 mg tab Losartan K 50 mg, hydrochlorothiazide 12.5 mg. Per 100 mg/25 mg tab Losartan K 100 mg, hydrochlorothiazide 25 mg
Indications/Uses
Dosage/Direction for Use
Adult Initial & maintenance: One 50 mg/12.5 mg tab once daily. Patient who do not respond adequately Adjust to a max dose of one 100 mg/25 mg tab daily or two 50 mg/12.5 mg tab daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to losartan K, hydrochlorothiazide or other sulfonamide-derived drugs. Anuria. Pregnancy (2nd & 3rd trimesters).
Special Precautions
Do not initiate treatment in patients who are intravascularly vol-depleted (eg, those treated w/ high-dose diuretics); hepatic & severe renal impairment. May increase BUN & serum creatinine in patients w/ bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Pregnancy (1st trimester) & lactation.
Adverse Reactions
Abdominal pain, edema/swelling, asthenia/fatigue, headache; palpitation; diarrhea, nausea; back pain; dizziness; dry cough, sinusitis, bronchitis, pharyngitis, upper resp tract infection; rash.
Drug Interactions
Losartan K: Increased AUC w/ cimetidine. Reduced AUC w/ phenobarb. Decreased levels w/ rifampicin & fluconazole. Increased serum K w/ K-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements or K-containing salt substitutes. Hydrochlorothiazide: Potentiation of orthostatic hypotension w/ alcohol, barbiturates or narcotics. Insulin & oral antidiabetic agents. Impaired absorption w/ cholestyramine & colestipol resins. Intensified electrolyte depletion particularly hypokalemia w/ corticosteroids, ACTH. Possible decreased response to pressor amines (eg, adrenaline). Potential increased responsiveness to nondepolarizing skeletal muscle relaxants (eg, tubocurarine). Reduced renal clearance & increased risk of lithium toxicity. Diuretic, natriuretic & antihypertensive effects may be reduced by NSAIDs.
ATC Classification
C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Losarite 100 mg/25 mg tab
Packing/Price
50's (P875/box, P17.5/tab)
Form
Losarite 50 mg/12.5 mg tab
Packing/Price
50's (P700/box, P14/tab)
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