In combination w/ lenalidomide & dexamethasone: Recommended initial ixazomib dose: 4 mg once wkly on days 1, 8 & 15 of a 28-day treatment cycle. Recommended initial lenalidomide dose: 25 mg daily on days 1-21 of a 28-day treatment cycle. Recommended initial dexamethasone dose: 40 mg on days 1, 8, 15 & 22 of a 28-day treatment cycle. Moderate or severe hepatic impairment, severe renal impairment or ESRD requiring dialysis
Initial dose: 3 mg. In the event that Ninlaro dose is delayed or missed, the dose should be taken only if the next scheduled dose is ≥72 hrs away. A missed dose should not be taken w/ in 72 hrs of the next scheduled dose. A double dose should not be taken to make up for a missed dose. If a patient vomits after taking a dose, the patient should not repeat the dose but should resume dosing at the time of the next scheduled dose.