Pentasa

Pentasa

mesalazine

Manufacturer:

Ferring

Distributor:

Metro Drug
Concise Prescribing Info
Contents
Mesalazine
Indications/Uses
Tab: Treatment of mild to moderate ulcerative colitis & Crohn's disease. Supp: Treatment of acute attacks of mild to moderate acute ulcerative proctitis. Maintenance of remission of ulcerative proctitis.
Dosage/Direction for Use
Tab Ulcerative colitis Adult Up to 4 g daily in divided doses. Maintenance: Up to 2 g daily in divided doses. Childn 20-30 mg/kg daily, ≥6 yr Initially 30-50 mg/kg/day in divided doses, max: 75 mg/kg/day in divided doses. Max total dose: 4 g/day. Maintenance: Initially 15-30 mg/kg/day in divided doses. Max total dose: 2 g/day. Crohn's disease Adult Up to 4 g daily in divided doses. Childn 20-30 mg/kg daily in divided doses, ≥6 yr Initially 30-50 mg/kg/day in divided doses, max: 75 mg/kg/day in divided doses. Max total dose: 4 g/day. Maintenance: Initially 15-30 mg/kg/day in divided doses. Max total dose: 4 g/day. Supp Ulcerative proctitis 1 supp once-bid.
Administration
May be taken with or without food: Swallow whole, do not chew/crush. If necessary, tab may also be halved along score-line or suspended in water/juice immediately before use.
Contraindications
Hypersensitivity to mesalazine or salicylates. Severe liver or renal impairment.
Special Precautions
Patients allergic to sulphasalazine. Assess liver function parameters & perform blood test for differential blood count prior to & during treatment. Regularly monitor renal function especially during initial phase of treatment. Discontinue if hematological effects, inflammation of cardiac muscle, blood dyscrasias occur. Pregnancy & lactation.
Adverse Reactions
Gastric discomfort (nausea & frequent urge to defecate), headache, rash, urticaria, eczema, hypersensitivity reactions.
Drug Interactions
May increase the risk of blood dyscrasia w/ azathioprine or 6-mercaptopurine or thioguanine.
ATC Classification
A07EC02 - mesalazine ; Belongs to the class of aminosalicylic acid and similar antiinflammatory. Used in the treatment of intestinal inflammation.
Presentation/Packing
Form
Pentasa supp 1 g
Packing/Price
28's
Form
Pentasa PR tab 500 mg
Packing/Price
100's
Form
Pentasa PR tab 1 g
Packing/Price
60's
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