Perform liver function test prior to initiation. Cases of myopathy & rhabdomyolysis; immune-mediated necrotizing myopathy. Predisposing factors for rhabdomyolysis (eg, hyperthyroidism). Alcohol consumption. Unexplained muscle pain, tenderness or weakness accompanied by malaise of fever. Concomitant use w/ fibrates or lipid-modifying doses of niacin; colchicine. Discontinue use if markedly elevated creatinine kinase levels, diagnosed or suspected myopathy or risk factor predisposing to development of renal failure secondary to rhabdomyolysis occurs. Endocrine function. Use effective contraception during treatment in females of reproductive potential. Renal impairment. Childn. Elderly.