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Indications and Dosage
Oral
Gastritis, Peptic ulcer Adult: 100 mg tid, in the morning, evening and before bedtime.
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Administration
May be taken with or without food.
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Special Precautions
Pregnancy and lactation. Elderly.
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Adverse Reactions
Dizziness, drowsiness, dry mouth, constipation, diarrhoea, abdominal distention, nausea, vomiting, eructation; ALT, AST and BUN elevation, oedema, hyperbilirubinaemia; gynaecomastia, induction of lactation, menstrual disorders, hot flushes; leucopenia, leucocytosis, thrombocytopenia; rash, urticaria, eczema.
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Action
Description: Rebamipide is a mucosal protective agent and is postulated to increase gastric blood flow, prostaglandin biosynthesis and decrease free oxygen radicals.
Pharmacokinetics: Absorption: Time to peak plasma concentration: 2 hr. Distribution: Plasma protein binding: Approx 98%. Excretion: Via urine (approx 10%) as unchanged drug. Plasma elimination half-life: Approx 1.5 hr. |
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Storage
Store below 25°C.
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MIMS Class
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ATC Classification
A02BX14 - rebamipide ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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References
Anon. Rebamipide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 01/12/2015. Buckingham R (ed). Rebamipide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/12/2015. Mucosta (Otsuka). MIMS Philippines. http://www.mims.com/philippines. Accessed 01/12/2015.
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