ampicillin + sulbactam


Shin Poong


Concise Prescribing Info
Per 500 mg/250 mg inj Ampicillin Na 500 mg, sulbactam Na 250 mg. Per 1 g/500 mg inj Ampicillin Na 1 g, sulbactam Na 500 mg
Infections due to β-lactamase-producing H. influenza including resp tract, bones, joints & soft tissues; polymicrobial infections w/ mixed aerobic & anaerobic eg, diabetic foot, gynecological infections, & intra-abdominal infections; UTI due to susceptible organism.
Dosage/Direction for Use
Adult 0.5-3 g IV/IM in 3-4 divided doses a day. Max: 4 g/day. Mild infections 1.5-3 g/day. Moderate infections 6 g/day. Severe infections 12 g/day. Infant & childn 150 mg/kg/day in 3-4 divided doses daily. Neonate or premature baby 150 mg/kg/day in 2 divided doses daily for a wk after birth. Prevention of surgical infection 1.5-3 g IV/IM.
Hypersensitivity w/ penicillins. Infectious mononucleosis. Previous history of cholestatic jaundice or hepatic dysfunction.
Special Precautions
History of cephalosporin hypersensitivity. Predisposition to develop allergic reactions eg, bronchial asthma, rash & urticaria. Poor oral intake or receiving parenteral nutrition. Lymphatic leukemia or possibly HIV infection. Severe liver or moderate/severe renal disorder. Pregnancy & lactation. Elderly.
Adverse Reactions
Skin rashes (urticarial or maculopapular).
Drug Interactions
Decreased OCs efficacy. Decreased clearance of methotrexate. Decreased renal tubular secretion of ampicillin & sulbactam w/ probenecid. Increased frequency of skin rashes in patients receiving ampicillin w/ allopurinol. Reduced absorption of ampicillin w/ chloroquine.
MIMS Class
ATC Classification
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Sulvacil 500 mg/250 mg powd for inj
10 × 1's (P480/vial)
Sulvacil 1 g/500 mg powd for inj
10 × 1's
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