Metro Drug
Concise Prescribing Info
Timolol maleate
Reduction of elevated IOP in ocular HTN, chronic open-angle glaucoma, aphakic patients w/ glaucoma, secondary glaucoma, narrow angle & history of spontaneous or iatrogenically induced narrow-angle closure in the opposite eye in whom reduction of IOP is necessary. Concomitant therapy w/ ped glaucoma.
Dosage/Direction for Use
1 drop in the affected eye/s once daily or bid.
Hypersensitivity. Reactive airway disease, bronchial asthma or a history of bronchial asthma, severe COPD. Sinus bradycardia; sino-atrial block 2nd & 3rd degree AV block; overt cardiac failure; cardiogenic shock.
Special Precautions
CV disease including cardiac failure; patients w/ 1st degree heart block; asthma; mild/moderate COPD. Severe peripheral circulatory disturbance/disorders (eg, severe forms of Raynaud's disease or syndrome). May mask hypoglycemic symptoms in patients w/ DM; hyperthyroidism. Potential additive effect on IOP or known systemic effects of β-blockade. Choroidal detachment reported. Do not administer while wearing soft contact lenses. Remove contact lenses before application & reinsert not earlier than 15 min after use. Pregnancy & lactation.
Adverse Reactions
Ocular irritation; visual disturbances, tinnitus. Bradycardia, arrhythmia, hypotension, syncope, heart block, CVA, cerebral ischemia, CHF, palpitation, cardiac arrest, edema, claudication, Raynaud's phenomenon, cold hands & feet. Bronchospasm, resp failure, dyspnea, cough. Headache, asthenia, fatigue, chest pain. Alopecia, exacerbation of psoriasis. Anaphylaxis, angioedema, localized & generalized rash. Dizziness, depression, insomnia, nightmares, memory loss, increase in signs & symptoms of myasthenia gravis. Nausea, diarrhea, dyspepsia, dry mouth, abdominal pain. Decreased libido, Peyronie's disease, sexual dysfunction. SLE. Myalgia.
Drug Interactions
Mydriasis may occasionally occur w/ concomitant use of epinephrine. Potentiated systemic β-blockade w/ quinidine, SSRIs & timolol. Potential additive effects, hypotension, marked bradycardia w/ oral Ca entry blocker, catecholamine-depleting drugs, antiarrhythmics, parasympathomimetics or β-adrenergic blockers. May exacerbate rebound HTN which can follow w/drawal of clonidine.
ATC Classification
S01ED01 - timolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Timoptol eye soln 0.5%
5 mL x 1's
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