Fatigue, stomatitis, pharyngitis, dyspnea, chest pain, and neuropathy. Rare cases of hepatitis, colitis, and intestinal pneumonitis have occurred; fatalities. Serious renal events, including acute renal failure. MI & cerebrovascular events. Radiation pneumonitis & recall. Hypersensitivity. Bone marrow depression, w/ leucopenia, anaemia. GI toxicity, nausea & vomiting, diarrhea & anorexia; mucositis. Reversible increases in liver enzyme values; weakness & malaise, fever, pain, headache, skin rashes, desquamation, arthralgia, muscle cramps, wt loss, dehydration, peripheral oedema, alopecia, increased sweating, taste disturbance & conjunctivitis.