Trigenna

Trigenna

cefuroxime

Manufacturer:

Interphil

Distributor:

Interphil
Concise Prescribing Info
Contents
Cefuroxime axetil
Indications/Uses
Treatment of infections due to sensitive gm +ve & gm -ve bacteria, surgical prophylaxis & more active against H. influenzae & Neisseria gonorrhoeae.
Dosage/Direction for Use
Adult & adolescent ≥13 yr Pharyngitis/tonsillitis, acute bacterial maxillary sinusitis 250 mg bid for 10 days. Uncomplicated UTI & skin & skin structure infections 250 mg bid for 7-10 days. Acute bacterial exacerbations of chronic bronchitis 250 or 500 mg bid for 10 days. Secondary bacterial infection of acute bronchitis 250 or 500 mg bid for 5-10 days. Early lyme disease 500 mg bid for 20 days. Uncomplicated gonorrhea 1,000 mg once w/ single dose probenecid 1,000 mg. Childn Acute otitis media & bacterial maxillary sinusitis 250 mg bid for 10 days.
Administration
Should be taken with food: Take w/ or after meals.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Clostridium difficile-associated diarrhea. History of colitis; concurrent treatment w/ potent diuretics; renal or hepatic impairment of poor nutritional state, patients receiving protracted course of antimicrobial therapy & previously stabilized on anticoagulant therapy. Monitor prothrombin time in patients at risk. Pregnancy & lactation.
Adverse Reactions
Hypersensitivity reactions: Anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria, pseudomembranous colitis, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia, increased prothrombin time, hepatic impairment including hepatitis & cholestasis, jaundice, seizure, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, renal dysfunction.
Drug Interactions
Probenecid; antacids; combined estrogen/progesterone OCs.
MIMS Class
Cephalosporins
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Trigenna tab 500 mg
Packing/Price
(Compliance pack) 14's (P64/tab, P730/box);100's (P6,400/box, P64/tab)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in