Effects on the blood:
An immune thrombocytopenia attributed to atorvastatin has been reported in patient. Adverse hematological reactions had not been noted when the patient previously received simvastatin.
Effects on the liver:
Acute hepatitis was diagnosed in a woman 12 weeks after starting treatment with atorvastatin. She had previously been taking Simvastatin and Fenofibrate without adverse effect, but with persistent hypercholesterolemia. Following cessation of atorvastatin, liver function test returned to normal and the patient recommended simvastatin therapy again without adverse effect.
Effects on skeletal muscle:
Muscle disorders are well recognised adverse effect of lipid regulating drugs such as fibrates and statins.
A woman developed rhabdomyolysis two months after starting atorvastatin. The patient was already taking ciclosporin following renal transplantation and had a history of systemic lupus erythematus.
Effect on the skin:
Toxic epidermal necrolysis apparently caused by atorvastatin.