Uromes

Uromes

mesna

Manufacturer:

Korea United Pharma

Distributor:

Qualimed
Concise Prescribing Info
Contents
Mesna
Indications/Uses
Prevention of urothelial toxicity of oxazaphosphorines, ifosfamide & cyclophosphamide.
Dosage/Direction for Use
IV bolus 20% given on 3 occasions over 15-30 min at 4-hrly intervals. Patient at high risk of urotoxicity Increase dose to 40% given 4 times at 3-hrly intervals. IV infusion 20% by IV inj followed by 100% of total dose by IV infusion over 24 hr, then followed by 60% by infusion over 12 hr. The final 12-hr infusion may be replaced by 3 inj each of 20% dose at 4-hrly intervals.
Contraindications
Hypersensitivity to mesna & other thiol compd.
Special Precautions
Hypersensitivity. Higher incidence of allergic reactions in patients w/ autoimmune disorders. Hematuria. Childn. Elderly.
Adverse Reactions
Hydrodipsomania, vomiting, diarrhea, anorexia, dysgeusia; hypotension, tachycardia; cephalgia; melalgia; increase ALT & AST; leukocytopenia; pruritus, erythema, bleb, exanthem; inj site pain, malaise, edema, fever, fatigue.
Drug Interactions
Cisplatin. Erythromycin, oxytetracyclin, aminophylline, lipiodol, epirubicin, nitrogen mustard. False +ve test for urinary ketones.
ATC Classification
V03AF01 - mesna ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
Presentation/Packing
Form
Uromes soln for IV inj 100 mg/mL
Packing/Price
4 mL x 10 × 1's
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