Leukopenia, thrombocytopenia; occasionally, bleeding, anemia may occur.
Nausea, vomiting; occasionally, anorexia, dipsia, stomatitis, infection of the lip, abdominal pain, rectal bleeding, ileus, constipation, cacogeusia, and indigestion may occur.
Anaphylactoid syndrome (urticaria, dyspnea, angioedema) may occur. If they occur, the administration should be discontinued and/or appropriate therapy should be initiated.
Occasionally, alopecia, blister, rash may occur.
Occasionally, paraesthesia, peripheral neuritis, loss of deep tendon reflexes, dysbasia, convulsion, arthralgia, myalgia, headache, dizziness, depression, hyposomnia; rarely, confusion, coma, apprehension may occur.
Aspermia, gonad (testis, ovary) disorder may occur.
Acute shortness of breath and severe bronchospasm has been reported following the administration of this drug. These reactions have been encountered most frequently when this drug was used in combination with mitomycin-C.
Occasionally, dysuria, flush, phlebitis, local pain of injection site, sphacelism, boil or wart, lymph node pain, tachycardia may occur.
Extravasation during intravenous injection may lead to cellulitis and phlebitis. If the amount of extravasation is great, sloughing may occur.