Cytotoxic-induced neutropenia Adult & childn
500,000 u/kg SC/IV infusion over 30 min daily started not <24 hr after cytotoxic chemotherapy, continue until neutrophil count is normal usually up to 14 days. Myeloablative therapy followed by bone marrow transplantation
1 million u/kg IV infusion over 30 min or SC/IV infusion over 24 hr daily started not <24 hr after cytotoxic chemotherapy (& w/in 24 hr of bone marrow infusion), adjust according to neutrophil count. Mobilization of peripheral blood progenitor cells for autologous infusion
Monotherapy: 1 million u/kg SC inj/infusion (24 hr) daily for 5-7 days. Adjunct to myelosuppresive chemotherapy: 500,000 u/kg SC inj daily until neutrophil count is normal. SC Mobilization of peripheral blood progenitor cells in normal donors for allogeneic infusion Adult <60 yr & adolescent >16 yr
1 million u/kg daily for 4-5 days. Severe chronic neutropenia Adult & childn
Initially 1.2 million u/kg daily in sinlge or divided doses. Persistent neutropenia in HIV infection
Initially 100,000 u/kg daily increased until neutrophil count is normal. Max: 400,000 u/kg daily.