Shandong Qidu


Endure Medical
Concise Prescribing Info
Prevention of post-op inspections due to anaerobic bacteria particularly species of Bacteroides & anaerobic Strep. Septicaemia, bacteraemia, peritonitis, brain abscess, necrotizing pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis & post-op wound infections from which pathogenic anaerobes have been isolated.
Dosage/Direction for Use
IV infusion at an approx rate of 5 mL/min. Anaerobic infections 7 days. Prophylaxis against anaerobic infections: Abdominal (especially colorectal) & gynaecological surgery Adult 500 mg shortly pre-op, repeated every 8 hr. Oral doses of 200 mg or 400 mg every 8 hr to be started as soon as feasible. Childn 7.5 mg/kg every 8 hr. Treatment of established anaerobic infections Adult 500 mg every 8 hr. Childn 7.5 mg/kg every 8 hr. Initial loading dose: 15 mg/kg IV infused over 60 min.
Active CNS disease, blood disease & allergy.
Special Precautions
Liver disease. Discontinue use if ataxia or other CNS observed. Carry out leukocyte count before repeating treatment course. Patients w/ anaerobic infections accompanied by renal failure (administer in 8-12 hr interval). May inhibit metabolism of alcohol. Interference w/ diagnosis ie, urine turn dark red. Pregnancy & lactation. Elderly.
Drug Interactions
May inhibit metabolism of warfarin & other oral anticoagulants leading to prolonged prothrombin time. Reduced plasma conc w/ drugs eg, phenytoin Na & phenobarb which induce liver microsomal enzymes. Reduced activity of metabolism & excretion w/ drugs eg, cimetidine which is inhibit the activity of liver microsomal enzymes. May interfere metabolism of disulfiram. May interfere w/ amino transferase & LDH testing result by lowering cholesterol & triglyceride level.
MIMS Class
ATC Classification
J01XD01 - metronidazole ; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections.
Zolemet soln for infusion 5 mg/mL
100 mL x 1's
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