Endometrin

Endometrin

progesterone

Manufacturer:

Ferring

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Progesterone
Indications/Uses
Luteal support as part of an Assisted Reproductive Technology (ART) treatment program for infertile women.
Dosage/Direction for Use
Adult 100 mg administered vaginally bd-tds starting at oocyte retrieval & continuing for up to 10 wk total duration (or 12 wk of gestation).
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Undiagnosed vag bleeding. Known missed abortion or ectopic pregnancy. Severe hepatic dysfunction or disease. Known or suspected breast or genital tract cancer. Active arterial or venous thromboembolism or severe thrombophlebitis, or a history of these events. Porphyria.
Special Precautions
Discontinue treatment if MI, cerebrovascular disorders, arterial or venous thromboembolism (venous thromboembolism or pulmonary embolism), thrombophlebitis or retinal thrombosis are suspected. Mild to moderate hepatic dysfunction. History of depression. Epilepsy, migraine, asthma, cardiac or renal dysfunction; diabetes. May increase the risk of retinal vascular lesions. Terminate use in case of transient ischemic events, appearance of sudden severe headaches, or vision impairments related to papillary edema or retinal hemorrhage. Abrupt discontinuation may cause increased anxiety, moodiness & increased sensibility to seizures. Impaired liver or renal function. May affect the ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Headache; abdominal distention & pain, nausea; uterine spasm.
Drug Interactions
May increase elimination rate w/ rifampicin, carbamazepine or St. John's wort. May decrease elimination rate w/ ketoconazole & other cytochrome P450-3A4 inhibitors. May alter progesterone release & absorption from the vag tab when used w/ other vag products (eg, antifungals).
ATC Classification
G03DA04 - progesterone ; Belongs to the class of pregnen (4) derivative progestogens.
Presentation/Packing
Form
Endometrin vag tab 100 mg
Packing/Price
21's
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