Ferriprox

Ferriprox

deferiprone

Manufacturer:

Apotex

Distributor:

Pharmaforte
Concise Prescribing Info
Contents
Deferiprone
Indications/Uses
Fe overload in patients w/ thalassaemia major when deferoxamine therapy is contraindicated or inadequate.
Dosage/Direction for Use
FC tab 25 mg/kg tds. Total daily dose: 75 mg/kg. Oral soln 25 mg/kg tds. Total daily dose: 75 mg/kg/day. Max dose: 100 mg/kg/day. Patient weighing 90 kg 2,250 mg (22.5 mL) tds. Total daily dose: 6,750 mg, 80 kg 2,000 mg (20 mL) tds. Total daily dose: 6,000 mg, 70 kg 1,750 mg (17.5 mL) tds. Total daily dose: 5,250 mg, 60 kg 1,500 mg (15 mL) tds. Total daily dose: 4,500 mg, 50 kg 1,250 mg (12.5 mL) tds. Total daily dose: 3,750 mg, 40 kg 1,000 mg (10 mL) tds. Total daily dose: 3,000 mg, 30 kg 750 mg (7.5 mL) tds. Total daily dose: 2,250 mg tds, 20 kg 500 mg (5 mL) tds. Total daily dose: 1,500 mg.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. History of recurrent neutropenia or agranulocytosis. Concomitant use of medicinal products associated w/ neutropenia or those that can cause agranulocytosis. Pregnancy & lactation.
Special Precautions
Monitor neutrophil count wkly; discontinue therapy if infection occur. Do not initiate treatment if patient is neutropenic or has a baseline ANC <1.5 x 109/L. Obtain complete blood count, WBC, corrected for the presence of nucleated RBC, neutrophil & platelet count immediately upon diagnosis of neutropenia & repeat daily; continue for 3 consecutive wk following recovery. Rechallenge is not recommended in the event of neutropenia, & contraindicated in agranulocytosis. Monitor serum ferritin every 2-3 mth; plasma Zn conc. Consider interruption of treatment if serum ferritin falls <500 mcg/L. Consider treatment interruption if there is a persistent increase in serum ALT. HIV positive or other immunocompromised patients. Carefully monitor liver histology in thalassaemia patients. Urine may show reddish/brown discoloration due to the excretion of Fe-deferiprone complex. Renal or hepatic impairment. Women of childbearing potential must be advised to avoid pregnancy & take contraceptive measures. Neurological disorders in childn. Childn <6 yr. Oral soln: Allergic reactions may occur due to sunset yellow content.
Adverse Reactions
Nausea, abdominal pain, vomiting, chromaturia. Increased liver enzymes, neutropenia, agranulocytosis, headache, diarrhoea, arthralgia, increased appetite, fatigue.
Drug Interactions
Trivalent cation-dependent products eg, Al-based antacids. Vit C. Drugs associated w/ neutropenia or agranulocytosis.
ATC Classification
V03AC02 - deferiprone ; Belongs to the class of iron chelating agents. Used in iron overload.
Presentation/Packing
Form
Ferriprox FC tab 500 mg
Packing/Price
100's
Form
Ferriprox oral soln 100 mg/mL
Packing/Price
250 mL x 1's;500 mL x 1's
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