May lead to loss of blood glucose control w/ thiazides & other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers & INH. Alcohol & alcohol-containing medications. Danazol. Medicines w/ intrinsic hyperglycaemic activity. ACE inhibitors. Glibenclamide: May potentiate hypoglycemic action w/ NSAIDs & other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-adrenergic blockers; ciprofloxacin. Increased hypoglycaemic effect w/ possible onset of hypoglycaemic manifestations or even coma w/ miconazole. Phenylbutazone. May reduce hypoglycaemic effect & increased risk of hepatotoxicity w/ bosentan. May mask hypoglycaemia symptoms by β-blockers; clonidine, reserpine, guanethidine & sympathomimetics. Fluconazole. Reduction in antidiuretic activity of desmopressin. Hypoglycaemic effect may be reduced w/ colesevelam. Metformin HCl: Iodinated contrast materials, furosemide, nifedipine, cationic drugs. May increase risk of lactic acidosis w/ NSAIDs including cyclo-oxygenase II inhibitors, ACE inhibitos, AIIA, diuretics (especially loop diuretics). Organic cation transporters.