Individualized dosage w/ a max daily dose of sitagliptin 100 mg & metformin 2 g. Patient inadequately controlled w/ diet & exercise alone
50 mg/500 mg bd. May be titrated up to 50 mg/1,000 mg bd. Patient inadequately controlled on metformin monotherapy
Sitagliptin 50 mg bd + metformin already taken. Patient inadequately controlled on sitagliptin monotherapy
50 mg/500 mg bd. May be titrated up to 50 mg/1,000 mg bd. Switching from sitagliptin co-administered w/ metformin
Initiate w/ dose of sitagliptin & metformin already being taken. Patient inadequately controlled on dual combination therapy w/ any 2 of the following antihyperglycemic agents: sitagliptin, metformin, sulfonylurea or w/ insulin & metformin
Sitagliptin 50 mg bd + metformin dose based on glycemic control level. Patients currently on or initiating sulfonylurea may require lower sulfonylurea doses to reduce the risk of sulfonylurea-induced hypoglycemia. Gradual dose escalation to reduce GI effects associated w/ metformin.