Adult & childn ≥40 kg 375 mg every 8 hr or 625 mg every 12 hr, in more severe infections every 8 hr.
Severe infections 1 g every 12 hr.
Severe renal impairment CrCl <10 mL/min Adult 325 mg or 625 mg once daily.
Childn <40 kg 15 mg/3.75 mg/kg as a single daily dose. Max: 500 mg/125 mg.
Moderate renal impairment CrCl 10-30 mL/min Adult 375 mg or 625 mg bid.
Childn <40 kg 15 mg/3.75 mg/kg bid. Max: 500 mg/125 mg bid.
Haemodialysis Adult 2 doses of 375 mg every 24 hr + 2 doses of 375 mg during dialysis, to be repeated at the end of dialysis.
Childn <40 kg 15 mg/3.75 mg/kg once daily. Administer 15 mg/3.75 mg/kg after haemodialysis to restore circulating drug levels.