Adult & childn ≥40 kg 375 mg every 8 hr or 625 mg every 12 hr, in more severe infections every 8 hr. Severe infections 1 g every 12 hr. Severe renal impairment CrCl <10 mL/min Adult 325 mg or 625 mg once daily. Childn <40 kg 15 mg/3.75 mg/kg as a single daily dose. Max: 500 mg/125 mg. Moderate renal impairment CrCl 10-30 mL/min Adult 375 mg or 625 mg bid. Childn <40 kg 15 mg/3.75 mg/kg bid. Max: 500 mg/125 mg bid. Haemodialysis Adult 2 doses of 375 mg every 24 hr + 2 doses of 375 mg during dialysis, to be repeated at the end of dialysis. Childn <40 kg 15 mg/3.75 mg/kg once daily. Administer 15 mg/3.75 mg/kg after haemodialysis to restore circulating drug levels.
Hepatic & renal impairment. Perform careful enquiry concerning previous hypersensitivity reactions to penicillin, cephalosporins or other β-lactam agents prior to therapy initiation. History of penicillin hypersensitivity & atopic individuals; discontinue & institute appropriate alternative therapy if allergic reactions occur. Do not use to treat penicillin-resistant S. pneumoniae. Impaired renal function or receiving high Bactoclav dose. Avoid use if infectious mononucleosis is suspected. Concomitant use w/ allopurinol & anticoagulants. Prolonged use. Acute generalized exanthemous pustulosis (discontinue). Consider antibiotic-associated colitis in patients who present w/ diarrhea during therapy; discontinue if this occurs. Ensure periodic assessment of organ system functions, including renal, hepatic & hematopoietic function during prolonged therapy. Maintain adequate fluid intake & urinary output to reduce possibility of crystalluria. False positive results in glucose presence testing in urine may occur w/ non-enzymatic methods, & in Coombs' test. Pregnancy (avoid use especially during 1st trimester) & lactation.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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