May decrease antihypertensive effect & increase risk of nephrotoxicity w/ ACE inhibitors &/or AIIA. Increased plasma conc w/ azole antifungals eg, fluconazole, ketoconazole). May increase risk of GI bleeding w/ oral corticosteroids eg, prednisolone, or antiplatelet therapy (eg, clopidogrel, prasugrel). May increase risk of anticoagulant-induced bleeding w/ warfarin. May impair effect of β-blockers. May increase nephrotoxicity w/ cyclosporin & tacrolimus. Decrease effect of diuretics (thiazides, K-sparing diuretics, loop diuretics). May increase plasma levels of lithium. May increase risk of MTX toxicity.