Risk of serotonin syndrome w/ irreversible non-selective MAOIs; moclobemide; linezolid; selegiline, rasagiline; tramadol, sumatriptan & other triptans; antidepressants w/ serotonergic effect & herbal remedies containing St. John's wort (Hypericum perforatum
). Decreased seizure threshold w/ antidepressants (eg, TCAs, SSRIs, SNRIs) neuroleptics (phenothiazines, thioxanthenes & butyrophenones), mefloquin, bupropion, tramadol. CYP450 inhibitors & inducers. Decreased AUC of vortioxetine w/ rifampicin; carbamazepine, phenytoin. Potential increased risk of bleeding w/ anticoagulants or antiplatelet drugs. Enhanced effect w/ lithium or tryptophan.