Adequate caution in administration should be used as shock symptoms may rarely occur. If any related signs or symptoms, eg feeling unwell, oral cavity discomfort, stridor, dizziness, abnormal urge to defecate, tinnitus or diaphoresis occur, Cefspan must be discontinued immediately.
If signs of hypersensitivity reactions such as rash, urticaria, erythema, pruritus or fever occur, this product should be discontinued and appropriate measures should be taken.
Granulocytopenia or eosinophilia infrequently may occur. Rarely, thrombocytopenia may occur. Cefspan should be discontinued if any of these abnormalities is found. It has been reported that hemolytic anemia has occurred with other cephems.
Infrequently, an increase in SGOT, SGPT or alkaline phosphatase may occur.
Periodic monitoring of renal function is recommended as serious renal impairment, such as acute renal insufficiency may rarely occur. If any of these abnormalities is found, discontinuation of Cefspan and other appropriate measures should be taken.
In rare instances, a serious colitis, eg pseudomembranous colitis, manifested by blood in stools, may occur. Abdominal pain or frequent diarrhea requires appropriate measures, including prompt withdrawal of Cefspan. Infrequently vomiting, diarrhea, abdominal pain, stomach discomfort, heartburn or anorexia and rarely nausea, feeling of enlarged abdomen or constipation may occur.
In rare instances, interstitial pneumonia or PIE syndrome, manifested by fever, cough, dyspnea, abnormal chest x-ray or eosinophilia may occur. If any such symptoms occur, this product should be immediately discontinued and appropriate measures such as giving adrenocortical hormones should be taken.
Alteration in Bacterial Flora:
Rarely, stomatitis or candidiasis may occur.
Rarely, vitamin K deficiencies (eg, hypoprothrombinemia or bleeding tendencies) or vitamin B group deficiencies (eg, glossitis, stomatitis, anorexia or neuritis) may occur.
Rarely, headache or dizziness may occur.