enoxaparin sodium




Concise Prescribing Info
Enoxaparin Na
Treatment of unstable angina, non-Q-wave MI & acute ST-segment elevation MI (STEMI). Prophylaxis & treatment of thromboembolic disorders. Hemodialysis.
Dosage/Direction for Use
Unstable angina/non-Q-wave MI 1 mg/kg SC bid for 2-8 days. Acute STEMI W/ a thrombolytic agent, initially 30 mg IV bolus followed by 1 mg/kg SC w/in 15 min then 12 hrly for 8 days or until discharged. Max: 10,000 anti-Xa IU for the 1st 2 SC doses. Patient ≥75 yr 0.75 mg/kg 12 hrly. Max: 7,500 anti-Xa IU for the 1st 2 inj only. Do not administer an initial IV bolus dose. Prophylaxis of thromboembolic disorders Low to moderate risk: In general surgery, 20 mg SC once daily for 7-10 days. In patients undergoing surgery, give initial dose approx 2 hr pre-op. High risk: In orthopedic surgery, 40 mg SC once daily for 7-10 days, give initial dose approx 12 hr pre-op. In bedridden medical patients: 40 mg SC once daily for 6-14 days. Treatment of thromboembolic disease 1 mg/kg SC bid for 10 days or 1.5 mg/kg SC once daily for 10 days. Hemodialysis 0.5-1 mg/kg for a 4-hr session.
Acute bacterial endocarditis, major bleeding disorders, thrombocytopenia, active gastric or duodenal ulcer, hypersensitivity to enoxaparin, hemorrhagic stroke & in other patients w/ increased risk of hemorrhage. Not for IM route. Lactation.
Special Precautions
Renal impairment, uncontrolled arterial HTN or a history of GI ulceration.
Adverse Reactions
Thrombocytopenia, ecchymosis & other hemorrhagic manifestations.
Drug Interactions
Oral anticoagulants, platelet aggregation inhibitors, NSAIDs, aspirin or dextran.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AB05 - enoxaparin ; Belongs to the class of heparin group. Used in the treatment of thrombosis.
Clexane pre-filled inj 40 mg/0.4 mL
(w/ safety device) 2 × 1's
Clexane pre-filled inj 60 mg/0.6 mL
2 × 1's
Clexane pre-filled inj 80 mg/0.8 mL
2 × 1's
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