anti-d immunoglobulins




Concise Prescribing Info
Human anti-D Ig
Prevention of Rh(D) immunization in Rh(D) negative women during i) pregnancy/delivery of Rh(D) positive baby, ii) abortion/threatened abortion, ectopic pregnancy or hydatidiform mole, iii) transplacental hemorrhage resulting from antepartum hemorrhage, amniocentesis, chorionic biopsy or obstet manipulative procedures. Treatment of Rh(D) negative persons after incompatible transfusions of Rh(D) positive blood or other products containing RBC.
Dosage/Direction for Use
Slow IM Postpartum prophylaxis 1,000-1,500 IU given to the mother as soon as possible after delivery but not later than 72 hr postpartum. Antepartum & postpartum prophylaxis Initially 1,000-1,500 IU in the 28th wk of pregnancy, then same dose w/in 72 hr after delivery if the newborn is Rh(D) positive. After interruption of pregnancy, extrauterine pregnancy or hydatidiform mole before the 12th wk of pregnancy 600-750 IU; after the 12th wk of pregnancy or after amniocentesis or chorion biopsy 1,250-1,500 IU. Doses are to be given w/in 72 hr of the event or intervention. Following transfusion of Rh-incompatible blood 500-1,250 IU/10 mL of transfused blood over a period of several days.
Newborn infants, Rh(D) positive individuals.
Special Precautions
IgA deficiency, active immunisation.
Adverse Reactions
Local pain & tenderness at inj site. Occasionally, fever, malaise, headache, cutaneous reactions & chills.
ATC Classification
J06BB01 - anti-D (rh) immunoglobulin ; Belongs to the class of specific immunoglobulins. Used in passive immunizations.
Igamad inj 750 IU/mL
2 mL x 1's
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