Lindane


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Scabies
Adult: In patients who have failed or are intolerant to other approved therapies: As 1% lotion: Apply a thin layer to dry skin and rub in from the neck down to the toes. Wash off after 8-12 hours. Apply only once and do not re-treat. Treatment recommendation may vary among individual products or countries (refer to detailed product guideline).

Topical/Cutaneous
Head pediculosis, Pediculosis pubis
Adult: In patients who have failed or are intolerant to other approved therapies: As 1% shampoo: Apply approx 30 mL to dry hair thoroughly and allow to remain in place for 4 minutes. Add small quantities of water to hair until lather forms. Rinse hair thoroughly and dry with a clean towel; comb hair with a fine-tooth comb to remove nits. Amount of shampoo needed will vary depending on the length and density of hair. Max: 60 mL. Do not re-treat. Treatment recommendation may vary among individual products or countries (refer to detailed product guideline).
Contraindications
Hypersensitivity. Uncontrolled seizure disorders, conditions which may increase systemic absorption (e.g. crusted scabies, atopic dermatitis, psoriasis). Premature infants. Lactation.
Special Precautions
Patient with history of seizures, previous head trauma, CNS tumour, HIV infection, or other conditions which may increase risk of seizures (e.g. excessive alcohol consumption); other certain skin conditions. Patient weighing <50kg. Hepatic impairment. Infants, children, and elderly. Pregnancy. Not indicated as 1st-line treatment. Avoid using oil treatments, or oil-based hair dressings or conditioners prior to and after application on the affected area.
Adverse Reactions
General disorders and administration site conditions: Pain.
Nervous system disorders: Headache, paraesthesia, dizziness.
Skin and subcutaneous tissue disorders: Contact dermatitis, rash, alopecia, pruritus, urticaria.
Potentially Fatal: Neurotoxicity (e.g. seizures).
Patient Counseling Information
Itching may persist even after successful treatment and not necessarily an indication for further treatment.
MonitoringParameters
Monitor for signs and symptoms of neurologic toxicity.
Drug Interactions
May increase risk of seizures with drugs that may lower the seizure threshold  (e.g. antipsychotics, antidepressants, centrally active anticholinesterases, theophylline, isoniazid, meperidine, ciclosporin, mycophenolate mofetil, tacrolimus, penicillins, imipenem, quinolones, chloroquine, pyrimethamine, radiographic contrast agents, methocarbamol).
Action
Description: Lindane is a scabicide and pediculicide. It is directly absorbed by parasites and ova through the exoskeleton and stimulates the nervous system, thereby causing seizures and the eventual death of parasitic arthropods.
Pharmacokinetics:
Absorption: Slowly and incompletely absorbed through intact skin; increased absorption when applied to weeping or excoriated skin.
Distribution: Crosses the placenta and enters breast milk.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces. Elimination half-life: Approx 18 hours.
Chemical Structure

Chemical Structure Image
Lindane

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 727, Lindane. https://pubchem.ncbi.nlm.nih.gov/compound/Lindane. Accessed Feb. 22, 2021.

Storage
Store between 20-25°C.
ATC Classification
P03AB02 - lindane ; Belongs to the class of chlorine-containing agents used as ectoparasiticides.
References
Anon. Lindane. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 15/02/2021.

Anon. Lindane. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 15/02/2021.

Buckingham R (ed). Lindane. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/02/2021.

Lindane Lotion (VersaPharm Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 15/02/2021.

Lindane Shampoo (VersaPharm Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 15/02/2021.

Lindane Shampoo, Suspension (Morton Grove Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 19/02/2021.

Scaboma Lotion and Cream (Glenmark Pharmaceuticals Ltd.). MIMS Myanmar. http://www.mims.com/myanmar. Accessed 15/02/2021.

Disclaimer: This information is independently developed by MIMS based on Lindane from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
  • Hexin
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in