Lybalin

Lybalin

pregabalin

Manufacturer:

Biolab

Distributor:

Biopharm

Marketer:

Biopharm
Concise Prescribing Info
Contents
Pregabalin
Indications/Uses
Management of fibromyalgia, neuropathic pain associated w/ diabetic peripheral neuropathy, & postherpetic neuralgia. Adjunctive therapy for adult patients w/ partial onset seizures. Treatment of generalized anxiety disorders.
Dosage/Direction for Use
Fibromyalgia Initially 75 mg bid, may be increased to 150 mg bid w/in 1 wk. Max: 450 mg/day. Maintenance: 300-450 mg/day divided bid. Patients w/ insufficient benefit w/ 300 mg/day may be increased to 225 mg bid. Neuropathic pain Initially 50 mg tid, may be increased to 100 mg tid w/in 1 wk. Max: 300 mg/day. Partial-onset seizures Initially 75 mg bid or 50 mg tid. Max: 600 mg/day. Maintenance: 150-600 mg/day divided & given bid or tid. Postherpetic neuralgia Initially 75 mg bid or 50 mg tid. May be increased to 300 mg/day w/in 1 wk. Maintenance: 75-150 mg bid or 50-100 mg tid.  Patients w/ insufficient pain relief following 2-4 wk treatment w/ 300 mg/day may be treated w/ up to 300 mg bid or 200 mg tid. Generalized anxiety disorder Initially 150 mg daily, may be increased at wkly intervals in steps of 150 mg to a max of 600 mg daily.    
Administration
May be taken with or without food.
Contraindications
Hypersensitivity.
Special Precautions
W/draw gradually. Monitor for worsening of depression, suicidal thoughts or behavior &/or mood changes. Peripheral edema. Wt gain. Discontinue use if angioedema, myopathy or elevated creatine kinase levels occur. Decrease in platelet count. PR interval prolongation. Liver & kidney disease. May affect ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Abnormal coordination, abnormal gait, abnormal thinking, amnesia, anxiety, asthenia, ataxia, attention disturbance, balance disorder, confusion, depersonalization, depression, disorientation, dizziness, dysarthria, erectile dysfunction, euphoria, headache, hypertonia, hypesthesia, incoordination, irritability, lethargy, decreased libido, memory impairment, myasthenia, myoclonus, nervousness, neuropathy, paresthesia, somnolence, speech disorder, stupor, tremor, twitching, vertigo; pruritus; abdominal distention & pain, constipation, diarrhea, dry mouth, flatulence, gastroenteritis, nausea, vomiting; ecchymosis; edema, face edema, fluid retention, hypoglycemia, increased appetite, peripheral edema, wt gain; abnormal & blurry vision, conjunctivitis, diplopia, eye disorder, nystagmus, otitis media, tinnitus; arthralgia, back pain, leg cramps, muscle spasms, myalgia, pain; bronchitis, pharyngolaryngeal pain, sinusitis; anorgasmia, impotence, urinary frequency & incontinence; accidental injury, allergic reaction, chest pain, dyspnea, fatigue, abnormal feeling, feeling drunk, fever, flu syndrome, infection. 
Drug Interactions
Risk of angioedema w/ ACE inhibitors. Decreased absorption w/ gabapentin. Additive effect on edema & wt gain &/or fluid retention w/ thiazolidinedione.
ATC Classification
N03AX16 - pregabalin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Lybalin cap 75 mg
Packing/Price
56's
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