Macroban

Macroban

mupirocin

Manufacturer:

Atlantic Lab

Distributor:

Atlantic Pharma

Marketer:

Atlantic Pharma
Full Prescribing Info
Contents
Mupirocin.
Description
Each 100 g contains Mupirocin 2 g (Mupirocin 2% w/w).
Ointment in a white, translucent, water-soluble, polyethylene glycol base. Mupirocin is a topical antibacterial produced by Pseudomonas fluorescens with activity against most strains of staphylococci and streptococci and also some Gram-negative bacteria such as Haemophilus influenzae, Neisseria spp.
Action
Pharmacology: Pharamacodynamics: Mupirocin is an antibacterial that inhibits bacterial protein synthesis by binding to isoleucyl transfer RNA synthetase.
Pharmacokinetics: Only very small amounts of topically applied Mupirocin are absorbed into the systemic circulation where it is rapidly metabolized to monic acid which is excreted in the urine.
Indications/Uses
Treatment of impetigo caused by Staphylococcus aureus and beta-hemolytic streptococci, including Streptococcus pyogenes.
Treatment of localized infected eczema and folliculitis caused by Staphylococcus aureus.
Dosage/Direction for Use
Topical: Children 2 months and adults: Apply to affected area 3 times daily for up to 10 days.
Re-evaluate after 3-5 days if no clinical response.
Overdosage
There was no evidence of systemic absorption (< 1.1 nanograms per ml of whole blood) following application to lower arm of normal males with occlusion for 24 hours. In addition, intravenous infusions of 252 mg of mupirocin and single oral dose of 500 mg of mupirocin have been well tolerated in adults.
Contraindications
Hypersensitivity to Mupirocin, polyethylene glycol, or any component of the formulation.
Special Precautions
For external use only: Avoid mucosal surfaces and contact eyes.
Open wounds: Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidney. Do not use if absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment.
Sensitivity reaction: If a reaction suggesting sensitivity or chemical irritation occurs, discontinue treatment and institute appropriate alternative therapy.
Superinfection: Prolonged use of antibiotics may result in overgrowth of non susceptible organisms, including fungi.
Use In Pregnancy & Lactation
Use in Pregnancy: There are no adequate and well-controlled studies in pregnant woman; use during pregnancy only if clearly needed.
Use in Lactation: It is not known whether Mupirocin is distributed into breast milk. However, problems in humans have not been documented. Mupirocin is unlikely to be distributed into breast milk in significant amounts since virtually no systemic absorption occurs following topical administration.
Adverse Reactions
Mupirocin is usually well tolerated but local reactions such as burning, stinging, and itching may occur after the application of mupirocin to the skin.
Burning, stinging, or pain (1.5%); itching (1%); rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increase exudate (less than 1 %); systemic reaction (rare).
Drug Interactions
Problem has not been documented.
Storage
Store between 30°C, in a well-closed container. Protect from freezing.
MIMS Class
ATC Classification
D06AX09 - mupirocin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
Presentation/Packing
Oint (tube) 2% x 5 g x 1's, 15 g x 1's.
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