Generic Medicine Info
Indications and Dosage
Treatment and prophylaxis of infection in second- and third-degree burns
Adult: As 8.5% cream: Apply a layer approx 1/16 inch 1-2 times daily. Continue until wound healing progresses or burn site ready for grafting. As 5 % soln: Wet an 8-ply burn dressing w/ soln and cover graft area. Keep dressing wet by using syringe or irrigation tubing (4 hrly or as necessary) or by moistening the dressing (6-8 hrly or as necessary). Continue until autograft vascularisation occurs and wound healing progresses. Wound dressing may be left in place for up to 5 days.
Child: As 8.5% cream: Same as adult dose. As 5% soln: ≥3mth Same as adult dose.
Powd for soln: Add 50 g of mafenide to 1000 mL of sterile water or NaCl 0.9% for irrigation to provide a 5% soln. Mix until dissolved.
Hypersensitivity to sulfonamides.
Special Precautions
Patient w/ G6PD deficiency, pulmonary dysfunction. Renal impairment. Childn. Pregnancy and lactation.
Adverse Reactions
Significant: Hyperventilation w/ resulting resp alkalosis, metabolic acidosis, fungal or bacterial superinfection.
Resp: Dyspnoea, decreased pCO2.
Endocrine: Hyperchloraemia.
Haematologic: Eosinophilia, porphyria, bleeding.
Dermatologic: Pain or burning sensation, rash, pruritus, facial oedema, swelling, urticaria, blisters, erythema, excoriation, hives, blisters.
Monitoring Parameters
Monitor acid-base balance, signs of infection and healing.
Description: Mafenide is a short-acting sulfonamide topical antibacterial agent that has a wide spectrum of activity. It has no definite mechanism of action, however, it appears to interfere w/ bacterial cellular metabolism. It has bacteriostatic action against many gm+ve and gm-ve organisms, including Pseudomonas aeruginosa and some anaerobes.
Absorption: Absorbed systemically from burned surface. Time to peak plasma concentration: 2 -4 hr (cream).
Metabolism: Metabolised to p-carboxybenzenesulfonamide, a weak carbonic anhydrase inhibitor.
Excretion: Via urine, as metabolites.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Mafenide, CID=3998, (accessed on Jan. 21, 2020)

Powd for soln: Store between 15-30°C. Cream: Store below 40°C. Protect from excessive heat.
MIMS Class
ATC Classification
D06BA03 - mafenide ; Belongs to the class of topical sulfonamides used in the treatment of dermatological diseases.
Anon. Mafenide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 05/07/2017.

Buckingham R (ed). Mafenide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 05/07/2017.

Mafenide Acetate Powder, for Solution (Par Pharmaceutical Inc). DailyMed. Source: U.S. National Library of Medicine. Accessed 05/07/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Mafenide Acetate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). Accessed 05/07/2017.

Sulfamylon Cream (Mylan Institutional Inc). DailyMed. Source: U.S. National Library of Medicine. Accessed 05/07/2017.

Disclaimer: This information is independently developed by MIMS based on Mafenide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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