Midecamycin


Concise Prescribing Info
Indications/Uses
Susceptible infections.
Dosage/Direction for Use
Adult : PO As acetate: 0.9-1.8 g/day in 2-3 divided doses.
Dosage Details
Oral
Susceptible infections
Adult: As acetate: 0.9-1.8 g daily in 2-3 divided doses.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Patients who previously developed liver disorders while receiving the drug.
Special Precautions
Hepatic or renal impairment; prolongation of QT interval; porphyria; pregnancy; lactation.
Adverse Reactions
GI disturbances; hypersensitivity reactions; cholestatic jaundice; CV effects; myasthenia-like syndrome.
Drug Interactions
Other drugs known to prolong QT interval. May reduce effect of oral contaceptives. Concentration possibly increased by cimetidine. Increased plasma concentration of warfarin, digoxin, theophylline, carbamazepine, ciclosporin. Increased risk of peripheral ischaemia with ergotamine.
Potentially Fatal: Ventricular arrhythmias with astemizole, terfenadine and cisapride.
Action
Description: Midecamycin binds reversibly to 50S ribosomal subunit causing blockade of transpeptidation/translocation reactions, inhibition of protein synthesis and thus inhibition of cell growth. Midecamycin has similar uses to erythromycin but is less active.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Midecamycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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