Bio Sidus


Cosma Medical
Concise Prescribing Info
Filgrastim (recombinant methionyl, human granulocyte colony stimulating factor)
Reduction in the duration of neutropenia & the incidence of febrile neutropenia in patients on chemotherapy. Patients receiving myeloablative chemotherapy followed by bone marrow transplantation. Mobilization of hematopoietic progenitor cells into the peripheral blood. Chronic administration for reducing the incidence & duration of neutropenia in patients w/ congenital, cyclic & idiopathic neutropenia. Reduction in the time required for neutrophil recovery & the duration of fever after induction or consolidation chemotherapy treatment of adults w/ acute myelogenous leukemia.
Dosage/Direction for Use
Chemotherapy-induced neutropenia 5 mcg/kg/day SC or IV Myeloablative chemotherapy followed by bone marrow transplantation 10 mcg/kg/day given 30 min or 24 hr IV infusion or continuous 24 hr SC infusion. Peripheral blood progenitor cell mobilization 10 mcg/kg SC once daily for 6-7 days w/ leukapheresis performed on day 5, 6, & 7. Severe chronic neutropenia 12 mcg/kg/day SC (single or divided dose). Idiopathic or cyclic neutropenia 5 mcg/kg/day SC (single or divided dose). Acute myelogenous leukemia 5 mcg/kg/day. Should be started at least 24 hr after chemotherapy & discontinued at least 24 hr before the next dose of chemotherapy.
Hypersensitivity. Should not be used to increase the dose of cytotoxic chemotherapy beyond established dosage regimens & should not be administered in patients w/ severe congenital neutropenia (Kostmann's syndrome) w/ abnormal cytogenetics.
Special Precautions
Malignancy w/ myeloid characteristics, premalignant myeloid condition. Monitor for WBC, platelet & hematocrit counts. Patients w/ high-dose chemotherapy. Monitor bone density in patients w/ osteoporotic bone disease w/ continuous therapy for >6 mth. Severe renal or hepatic impairment. Pregnancy & lactation.
Adverse Reactions
Musculoskeletal pain (controllable w/ analgesics), urinary abnormalities, decreased BP & raised liver enzyme. Nausea & vomiting, alopecia, diarrhea, fatigue, anorexia, mucositis, headache, cough, skin rash, chest pain, generalized weakness, sore throat, constipation & unspecified pain.
Drug Interactions
Chemotherapy (not recommended in the period from 24 hr before to 24 hr after).
ATC Classification
L03AA02 - filgrastim ; Belongs to the class of colony stimulating factors. Used as immunostimulants.
Neutromax inj 300 mcg/mL
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Neutromax inj 480 mcg/1.6 mL
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