Slow continuous IV infusion at a conc of 0.1 mg/mL. Gradual reduction in BP
Initially 50 mL/hr (5 mg/hr). If desired BP reduction is not achieved at this dose, infusion rate may be increased by 25 mL/hr (2.5 mg/hr) 15 min or every 5 min for more rapid BP reduction up to a max of 150 mL/hr. Following achievement of the BP goal, the infusion rate should be decreased to 30 mL/hr (3 mg/hr). Hypotension or tachycardia
Infusion may be restarted at low doses eg, 30-50 mL/hr (3-5 mg/hr) & adjusted to maintain desired BP when BP has stabilized.