Chest pain, edema, flushing, palpitation, stroke, syncope, tachycardia, vascular thrombotic disease; aggressive behavior, depression, dizziness, drowsiness, emotional instability, fatigue, headache, insomnia, lethargy, malaise, nervousness, paresthesia, pseudotumor cerebri, psychosis, seizure, stroke, suicidal ideation, attempts & behavior; abnormal wound healing, acne fulminans, alopecia, bruising, cheilitis, dry nose & skin, eczema, eruptive xanthomas, facial erythema, skin fragility, hirsutism, hyper- & hypopigmentation, increased sunburn susceptibility, nail dystrophy, paronychia, peeling of palms & soles, photoallergic & photosensitizing reactions, pruritus, purpura, rash; increased triglycerides, blood glucose, cholesterol, abnormal menses, decreased HDL, hyperuricemia; bleeding & inflammation of the gums, colitis, esophagitis, esophageal ulceration, inflammatory bowel disease, nausea, nonspecific GI symptoms, pancreatitis, wt loss, xerostomia; nonspecific urogenital findings; anemia, neutropenia, pyogenic granuloma, thrombocytopenia; increased alkaline phosphatase, ALT, AST, γ-glutamyl transpeptidase, LDH, hepatitis; back pain, arthralgia, arthritis, bone abnormalities, decreased bone mineral density, calcification of tendons & ligaments, increased CPK, myalgia, premature epiphyseal closure, skeletal hyperostosis, tendonitis, weakness; cataracts, color vision disorder, conjunctivitis, corneal opacities, dry eyes, eyelid, inflammation, keratitis, decreased night vision, optic neuritis, photophobia, visual disturbances; hearing impairment, tinnitus; glomerulonephritis, hematuria, proteinuria, pyuria, vasculitis; bronchospasm, epistaxis, resp infection, voice alteration, Wegener's granulomatosis; allergic & anaphylactic reactions, disseminated herpes simplex, diaphoresis, infection, lymphadenopathy.
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