Siam Bheasach


Siam Pharmaceutical


Siam Pharmaceutical
Concise Prescribing Info
Adjunctive treatment of severe systemic fungal infection caused by suscpetible strains of Candida or Cryptococcus. Chromoblastomycosis caused by susceptible fungi. In combination w/ amphotericin B for candidiasis & cryptococcosis due to rapid emergence of resistance to flucytosine in Candida & Cryptococcus.
Dosage/Direction for Use
50-150 mg/kg once daily in 4 equally divided doses at 6-hr intervals. Patients w/ renal impairment CrCl >40 mL/min 25 mg/kg/dose every 6 hr, 20-40 mL/min 25 mg/kg/dose every 12 hr, 10-20 mL/min 25 mg/kg/dose every 24 hr, <10 mL/min 25 mg/kg/dose every 48 hr. End-stage renal disease on on intermittent hemodialysis 25-50 mg/kg every 48-72 hr after hemodialysis.
May be taken with or without food.
Special Precautions
Contraindicated in known hypersensitivity. May be harmful to kidneys, liver & bone marrow. Extreme caution in patients w/ bone marrow depression; hematologic disease, are treated or has a history of being treated w/ radiation or marrow suppressant drugs. Frequently monitor hepatic function & hematopoietic system during therapy; blood levels in patients w/ renal function impairment; hematologic status (WBC & platelet count) & liver function (alkaline phosphatase, ALT & AST) during treatment. Determine electrolytes, hematological & renal status prior to initiation of therapy. Pregnancy & lactation.
Adverse Reactions
Cardiac arrest, myocardial toxicity, ventricular dysfunction; ataxia, confusion, seizure, fatigue, hallucination, headache, hearing loss, paresthesia, parkinsonism, peripheral neuropathy, psychosis, pyrexia, sedation, vertigo, weakness; abdominal pain, anorexia, bilirubin elevation, diarrhea, dry mouth, duodenal ulcer, emesis, GI hemorrhage, hepatic dysfunction, hepatic enzymes elevation, acute hepatic injury, jaundice, nausea, ulcerative colitis; myelosuppression, agranulocytosis, aplastic anemia, anemia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia; photosensitivity, pruritus, rash, toxic epidermal necrolysis, urticaria; azotemia, creatinine elevation, BUN elevation, crystalluria, renal failure; chest pain, dyspnea, resp arrest; allergic reactions, hypoglycemia, hypokalemia.
Drug Interactions
May enhance adverse effect w/ amphotericin B. May diminish therapeutic effect w/ cytarabine. May increase risk of hematologic toxicity w/ zidovudine.
MIMS Class
ATC Classification
D01AE21 - flucytosine ; Belongs to the class of other antifungals for topical use.
Tozene cap 500 mg
10 × 10's
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