Thông tin thuốc gốc
Chỉ định và Liều dùng
Adult: For the treatment of bronchopulmonary diseases or conditions associated with excessive mucous secretion: 8 mg tid as needed, may be increased to 16 mg tid for the 1st 7 days.
Child: 2-5 years 2 mg tid or 4 mg bid (Max: 8 mg daily); 6-11 years 4-8 mg tid (Max: 24 mg daily); ≥12 years Same as adult dose. Treatment or dosage recommendations may vary among countries and individual products (refer to detailed product guideline).
Cách dùng
May be taken with or without food.
Thận trọng
Patient with existing or history of gastric ulceration; asthma. Severe renal and hepatic impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Rarely, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), acute generalised exanthematous pustulosis.
Gastrointestinal disorders: Diarrhoea, nausea, vomiting, upper abdominal pain.
Immune system disorders: Hypersensitivity reaction (including anaphylactic reaction and shock, angioedema, bronchospasm).
Investigations: Increased serum amino transaminase (transient).
Nervous system disorders: Headache, dizziness.
Skin and subcutaneous tissue disorders: Rash, sweating, urticaria, pruritus.
Tương tác
Enhances the penetration of antibiotic agents (e.g. amoxicillin, erythromycin, cefuroxime) into bronchial secretions.
Tác dụng
Mechanism of Action: Bromhexine is a mucolytic agent that acts on the mucus gland in the respiratory tract to change the structure of bronchial secretion. It enhances the transport of mucus by reducing its viscosity and increases cilia activity resulting in enhanced mucociliary clearance. This secretolytic and secretomotor effect in the bronchial tract facilitates expectoration and relieves cough.
Absorption: Rapidly and completely absorbed from the gastrointestinal tract. Bioavailability: Approx 22.2 ± 8.5% (tab); 26.8 ± 13.1% (oral solution). Time to peak plasma concentration: Approx 1 hour.
Distribution: Crosses blood brain-barrier; placenta (small amounts). Plasma protein binding: 95% (unchanged drug).
Metabolism: Almost completely metabolised to a variety of hydroxylated metabolites, including ambroxol and dibromanthranilic acid. Undergoes extensive hepatic first-pass metabolism.
Excretion: Via urine (approx 97.4 ± 1.9%; <1% as unchanged drug). Terminal elimination half-life: 6.6-31.4 hours (single dose).
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Bromhexine, CID=2442, (accessed on Jan. 21, 2020)

Bảo quản
Store below 30°C. Protect from light. Storage recommendations may vary among individual products. Refer to detailed product guidelines.
Phân loại MIMS
Thuốc ho & cảm
Phân loại ATC
R05CB02 - bromhexine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Tài liệu tham khảo
Anon. Bromhexine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 08/02/2022.

Axcel Bromhexine Syrup (Kotra Pharma [M] Sdn. Bhd.). MIMS Malaysia. Accessed 18/02/2022.

Buckingham R (ed). Bromhexine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 08/02/2022.

Pharmacy Retailing (NZ) Limited trading as Healthcare Logistics. Bisolvon Chesty Forte Tablets and Oral Solution data sheet 20 December 2021. Medsafe. Accessed 08/02/2022.

Rexom Bromhexine Elixir (KCK Pharmaceutical Industries Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. Accessed 18/02/2022.

RiteMed Bromhexine Tablet (Ritemed Phils, Inc). MIMS Philippines. Accessed 18/02/2022.

Vasican Tablets 8 mg (Actavis Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. Accessed 18/02/2022.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Bromhexine từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2024 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi
  • Axcel Bromhexine
  • Biovon
  • Bisinthvon
  • Bisolvon inj
  • Bivo
  • Bromhexin 4 F.T.Pharma
  • Bromhexin 8 F.T.Pharma
  • Bromhexin 8 Vacopharm
  • Bromhexin Actavis
  • Bromhexin Balkanpharma
  • Bromhexin Daewoo
  • Bromhexin DOMESCO
  • Bromhexin NIC Pharma
  • Bromhexin Pharbaco
  • Bromhexyl
  • Disolvan
  • Dosulvon
  • Duo Hexin
  • Eftisovol Elixir
  • Ekxine
  • Expecto
  • Flamolyte
  • Meko Lysin
  • Mucoxin
  • Paxirasol
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in