This drug may cause headache, dizziness, nervousness, sleeplessness and fatigue which may impair ability to drive or operate machinery.
Monitor renal function. Observe for signs and symptoms of anaphylaxis during 1st dose.
Symptoms: Nausea, hallucinations, hyperreflexia, extrapyramidal symptoms, clouded consciousness, or even coma and renal function impairment. Management: Induce vomiting at once or gastric lavage; haemodialysis if needed. Monitor and if necessary, correct water and electrolyte balance.
Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.
Positive direct Coombs test. False-positive urinary glucose test using cupric sulfate (Benedict's soln, Clinitest®, Fehling's soln). False-positive serum or urine creatinine w/ Jaffe' reaction.
Description: Cefadroxil inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Pharmacokinetics: Absorption: Almost completely absorbed from the GI tract. Time to peak plasma concentration: 1.5-2 hr. Distribution: Widely distributed to body tissues and fluids. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 20%. Excretion: Via urine (more than 90%, as unchanged drug). Plasma half-life: Approx 1.5 hr.
Store between 20-25°C. Reconstituted powd for susp: Store between 2-8°C.
J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
Anon. Cefadroxil. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/10/2014.Buckingham R (ed). Cefadroxil. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/07/2014.Cefadroxil capsule (Citron Pharma LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/10/2014.Cefadroxil, Powder for Suspension (Ranbaxy Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/10/2014.McEvoy GK, Snow EK, Miller J et al (eds). Cefadroxil. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/10/2014.Wickersham RM. Cefadroxil . Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 07/10/2014.