Cefadroxil


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Skin and skin structure infections, Streptococcal pharyngitis, Tonsillitis, Urinary tract infections
Adult: 1-2 g daily as a single or in 2 divided doses.
Child: ≥6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.
Renal Impairment
Patient on haemodialysis: An additional 0.5-1 g given after each dialysis session.
CrCl (mL/min) Dosage
≤10 0.5-1 g 36 hrly.
11-25 0.5-1 g 24 hrly.
26-50 0.5-1 g 12 hrly.
Hepatic Impairment
No dosage adjustment needed.
Cách dùng
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Hướng dẫn pha thuốc
Add the amount of water specified in the container in 2 portions to provide a susp containing 125, 250 or 500 mg per 5 mL. Shake the bottle after each addition.
Chống chỉ định
Hypersensitivity to cefadroxil or to other cephalosporins.
Thận trọng
History of hypersensitivity to penicillins or any other β-lactam drugs. History of GI disease (particularly colitis), severe allergies or asthma. Renal impairment. Pregnancy and lactation.
Phản ứng phụ
Dyspepsia, nausea, vomiting, diarrhoea; allergies (e.g. rash, urticaria, angioedema, pruritus); hepatic dysfunction (e.g. cholestasis, elevated serum transaminase); genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Rarely, agranulocytosis, thrombocytopenia, idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, arthralgia.
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Thông tin tư vấn bệnh nhân
This drug may cause headache, dizziness, nervousness, sleeplessness and fatigue which may impair ability to drive or operate machinery.
MonitoringParameters
Monitor renal function. Observe for signs and symptoms of anaphylaxis during 1st dose.
Quá liều
Symptoms: Nausea, hallucinations, hyperreflexia, extrapyramidal symptoms, clouded consciousness, or even coma and renal function impairment. Management: Induce vomiting at once or gastric lavage; haemodialysis if needed. Monitor and if necessary, correct water and electrolyte balance.
Tương tác
Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.
Lab Interference
Positive direct Coombs test. False-positive urinary glucose test using cupric sulfate (Benedict's soln, Clinitest®, Fehling's soln). False-positive serum or urine creatinine w/ Jaffe' reaction.
Tác dụng
Description: Cefadroxil inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Pharmacokinetics:
Absorption: Almost completely absorbed from the GI tract. Time to peak plasma concentration: 1.5-2 hr.
Distribution: Widely distributed to body tissues and fluids. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 20%.
Excretion: Via urine (more than 90%, as unchanged drug). Plasma half-life: Approx 1.5 hr.
Đặc tính

Chemical Structure Image
Cefadroxil

Source: National Center for Biotechnology Information. PubChem Database. Cefadroxil, CID=47965, https://pubchem.ncbi.nlm.nih.gov/compound/Cefadroxil (accessed on Jan. 21, 2020)

Bảo quản
Store between 20-25°C. Reconstituted powd for susp: Store between 2-8°C.
Phân loại MIMS
Phân loại ATC
J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
References
Anon. Cefadroxil. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/10/2014.

Buckingham R (ed). Cefadroxil. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/07/2014.

Cefadroxil capsule (Citron Pharma LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/10/2014.

Cefadroxil, Powder for Suspension (Ranbaxy Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/10/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Cefadroxil. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/10/2014.

Wickersham RM. Cefadroxil . Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 07/10/2014.

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