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Chỉ định và Liều dùng
Intravenous
Susceptible infections Adult: As sodium: 1-2 g daily in 2 divided doses by injection/infusion.
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Chống chỉ định
Infectious mononucleosis, lymphatic leukaemia, HIV infection; hypersensitivity to penicillins.
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Thận trọng
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum K concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.
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Phản ứng phụ
Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropaenia; thrombocytopaenia; CNS toxicity including convulsions; diarrhoea; nausea; vomiting.
Potentially Fatal: Pseudomembranous colitis. |
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Tương tác
Prolonged 1/
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Lab Interference
May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
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Tác dụng
Description: Cefpiramide is active against P. aeruginosa, but possibly less active against Enterobacteriaceae. It is also active against staphylococci and streptococci and marginally active against enterococci in vitro. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis.
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