Thông tin thuốc gốc
Chỉ định và Liều dùng
Acute otitis media
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.

Skin and soft tissue infections
Adult: 200-400 mg 12 hrly.
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.

Respiratory tract infections, Urinary tract infections
Adult: 100-200 mg 12 hrly.
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.

Uncomplicated gonorrhoea
Adult: 200 mg as a single dose.
Renal Impairment
Patient on haemodialysis: Dose should be given after each dialysis session.
CrCl (mL/min)
<10 Increase dosing intervals to 48 hrly.
10-39 Increase dosing intervals to 24 hrly.
Cách dùng
Should be taken with food.
Hướng dẫn pha thuốc
Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.
Chống chỉ định
Hypersensitivity to cefpodoxime or other cephalosporins.
Thận trọng
Patient w/ history of penicillin allergy. Renal impairment. Childn. Pregnancy and lactation.
Phản ứng phụ
Diarrhoea, nausea, abdominal pain, vomiting, diaper and skin rash, headache, vag infection. Anxiety, chest pain, cough, decreased appetite, dizziness, dysgeusia, epistaxis, eye pruritus, fatigue, fever, flatulence, flushing, fungal skin infection, hypotension, insomnia, malaise, nightmares, pruritus, purpuric nephritis, tinnitus, weakness, xerostomia, vulvovaginal candidiasis.
Potentially Fatal: Anaphylaxis, Clostridium difficile-associated diarrhoea and colitis.
Monitor renal function; observe for signs and symptoms of anaphylaxis during 1st dose.
Quá liều
Symptoms: Nausea, vomiting, epigastric distress and diarrhoea. Management: Haemodialysis or peritoneal dialysis may be useful in the event of a serious toxic reaction particularly if renal function is compromised.
Tương tác
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion w/ probenecid.
Food Interaction
Cefpodoxime levels may be increased w/ food.
Lab Interference
Urinary glucose test using cupric sulfate (e.g. Benedict's or Fehling's tests soln, Clinitest®) may produce false-positive result. May induce a positive direct Coombs' test; false-positive serum or urine creatinine w/ Jaffe' reaction.
Tác dụng
Description: Cefpodoxime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Rapid and well absorbed from the GI tract (approx 50%). Decreased absorption in low gastric acidity conditions. Food may increase bioavailability. Bioavailability: Approx 50%. Time to peak plasma concentration: Approx 2-3 hr.
Distribution: Reaches bile, resp and genito-urinary tract (therapeutic concentrations); enters breast milk (low concentrations). Plasma protein binding: Approx 20-30%.
Metabolism: De-esterified to cefpodoxime in the intestinal lumen.
Excretion: Via urine (80% as unchanged drug). Plasma half-life: Approx 2-3 hr.
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Cefpodoxime, CID=6335986, https://pubchem.ncbi.nlm.nih.gov/compound/Cefpodoxima (accessed on Jan. 21, 2020)

Bảo quản
Store between 20-25°C. Reconstituted powd: Store between 2-8°C.
Phân loại MIMS
Anon. Cefpodoxime. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 13/11/2014.

Buckingham R (ed). Cefpodoxime Proxetil. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/11/2014.

Cefpodoxime Proxetil Granule, for Suspension (Sandoz Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 13/11/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Cefpodoxime Proxetil. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 13/11/2014.

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