Fenbufen

Oral
Pain and inflammation associated with musculoskeletal and joint disorders

Should be taken with food. Take w/ or immediately after meals.

Hypersensitivity to fenbufen or other NSAIDs. Lactation.

Patient w/ gastric ulcer, cardiac disorders. Renal or hepatic impairment. Pregnancy.

Nervous: Depression, dizziness, headache, numbness.
GI: Anorexia, vomiting, abdominal pain, heartburn, diarrhoea, black stool, constipation, dry/sore mouth.
Resp: Wheezing, dyspnoea.
Ophthalmologic: Visual disturbance.
Otic: Tinnitus.
Dermatologic: Rash, toxic epidermal necrolysis, oedema, photosensitivity.
Others: Fatigue.
Potentially Fatal: Erythema multiforme, Stevens-Johnson syndrome.

This drug may cause blurred vision, if affected, do not drive or operate machinery.

Decreased serum concentration w/ aspirin. Risk of convulsions when given w/ quinolones (e.g. enoxacin, ofloxacin). May enhance the anticoagulant effect of coumarins.

Description: Fenbufen is a propionic acid derivative which prevents the synthesis of prostaglandins by inhibiting cyclooxygenase.
Pharmacokinetics:
Absorption: Absorbed from the GI tract. Time to peak plasma concentration: Approx 70 min.
Distribution: Enters breast milk (small amounts). Plasma protein binding: >99%.
Metabolism: Metabolised in the liver to active metabolites, biphenylacetic acid and 4-hydroxy-biphenylbutyric acid.
Excretion: Via urine (mainly as conjugates). Plasma half-life: Approx 10-17 hr.

Source: National Center for Biotechnology Information. PubChem Database. Fenbufen, CID=3335, https://pubchem.ncbi.nlm.nih.gov/compound/Fenbufen (accessed on Jan. 20, 2020)

Store below 25°C.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

M01AE05 - fenbufen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.

Anon. Fenbufen. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/02/2017 .

Buckingham R (ed). Fenbufen. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/02/2017 .

Preston CL (ed). Fenbufen Interactions. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/02/2017 .