Thông tin thuốc gốc
Chỉ định và Liều dùng
Adult: Initially, 30 mg daily in single or divided doses, until improvement occurs. Increase if necessary after 4 wk up to 60 mg daily for 4-6 wk. Once response is obtained, may gradually reduce to maintenance of 10-20 mg daily, and up to 40 mg daily may be needed in some cases.
Elderly: 5-10 mg daily.
Suy thận
Severe: Contraindicated.
Suy gan
Chống chỉ định
Cerebrovascular disorders, severe CV disease, actual or suspected phaeochromocytoma. Hepatic and severe renal impairment. Concomitant admin w/ other MAOIs, SSRIs or TCAs, indirectly-acting sympathomimetic agents, dopamine or levodopa, other CNS depressants, stimulants, local anaesth, ganglion-blocking agents and other hypotensives, diuretics, vasopressors, anticholinergic drugs and hypoglycaemic agents, pethidine.
Thận trọng
Patient w/ CV disease, DM or blood dyscrasias. Avoid abrupt withdrawal. Mild to moderate renal impairment. Elderly and debilitated patients. Pregnancy and lactation.
Tác dụng không mong muốn
Orthostatic hypotension, associated in some patients w/ disturbances in cardiac rhythm, peripheral oedema, complaints of dizziness, dry mouth, nausea and vomiting, constipation, blurred vision, insomnia, drowsiness, weakness and fatigue. Infrequent reports of mild headaches, sweating, paraesthesia, peripheral neuritis, hyperreflexia, agitation, overactivity, muscle tremor, confusion and other behavioural changes, difficulty in micturition, impairment of erection and ejaculation, skin rashes, increased appetite, wt gain. Rarely, blood dyscrasias (e.g. purpura, granulocytopenia).
Thông tin tư vấn bệnh nhân
This drug may cause drowsiness, if affected, do not drive or operate machinery. Eat only fresh food and avoid food that is suspected of being stale or 'going off'. Avoid alcoholic drinks or de-alcoholised (low alcohol) drinks.
Chỉ số theo dõi
Perform regular monitoring of liver function during therapy. Monitor BP, heart rate, mood, suicidal ideation (esp at the beginning of therapy or when doses are adjusted).
Quá liều
Symptoms: Dizziness, ataxia, irritability, hypotension or HTN, tachycardia, pyrexia, psychotic manifestations, convulsions, resp depression and coma. Management: Perform gastric lavage soon after ingestion and carry out intensive supportive therapy. May treat severe hypotension w/ plasma expanders. Hypertensive crises may be treated by pentolinium or phentolamine, severe shock w/ hydrocortisone. May use diazepam to control convulsions or severe excitement.
Tương tác
Potentially Fatal: May cause serotonin syndrome w/ other MAOIs, SSRIs or most TCAs (e.g. clomipramine, desipramine, imipramine, butriptyline, bortriptyline). May potentiate actions of indirectly-acting sympathomimetic agents (e.g. amfetamines, metaraminol, fenfluramine or similar anorectic agents, ephedrine or phenylpropanolamine), dopamine or levodopa, other CNS depressants (esp barbiturates and phenothiazines), stimulants, local anaesth, ganglion-blocking agents and other hypotensives, diuretics, vasopressors, anticholinergic drugs and hypoglycaemic agents. May cause serious, potentially fatal reactions when given w/ pethidine.
Tương tác với thức ăn
Avoid food or beverage w/ high tyramine content (e.g. mature cheese, hydrolysed yeast or meat extracts, alcoholic beverages, non-alcoholic beers, lagers, wines, and other food which are not fresh and are fermented, pickled, 'hung', 'matured' or otherwise subject to protein degradation before consumption); broad bean pods, banana skins, as these may cause sudden and severe high BP (hypertensive crisis or serotonin syndrome).
Tác dụng
Description: Isocarboxazid, a hydrazine derivative, is an irreversible inhibitor of both monoamine oxidase types A and B. It increases endogenous concentrations of epinephrine, norepinephrine, dopamine, and serotonin through inhibition of the enzyme, monoamine oxidase, responsible for the breakdown of these neurotransmitters.
Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: 3-5 hr.
Metabolism: Undergoes hepatic metabolism.
Excretion: Via urine mainly as metabolites.
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Isocarboxazid, CID=3759, (accessed on Jan. 21, 2020)

Bảo quản
Store at or below 25°C.
Phân loại MIMS
Thuốc chống trầm cảm
Phân loại ATC
N06AF01 - isocarboxazid ; Belongs to the class of non-selective monoamine oxidase inhibitors. Used in the management of depression.
Tài liệu tham khảo
Anon. Isocarboxazid. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 14/03/2016.

Buckingham R (ed). Isocarboxazid. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 14/03/2016.

Joint Formulary Committee. Isocarboxazid. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 14/03/2016.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Isocarboxazid từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2022 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in