Thông tin thuốc gốc
Chỉ định và Liều dùng
Parkinson's disease
Adult: Initially, 0.1 mg at bedtime, additional doses of 0.1 mg at wkly intervals may be given, 1st in the morning then at midday. Further increases of 0.1 mg wkly may be made until an optimum response is obtained, using the same sequence of increases, starting w/ the bedtime dose. Max: 2 mg daily in 3 or 4 divided doses.

Suppression of lactation
Adult: 0.2 mg bid to tid for 14 days starting w/in the 1st 24 hr of delivery or abortion.

Acromegaly, Hyperprolactinaemia-associated disorders
Adult: 0.1 mg in the evening of the 1st day, followed by 0.1 mg at midday and in the evening of the 2nd day, then 0.1 mg in the morning, at midday and in the evening of the 3rd day. Treatment is continued and adjusted according to prolactin levels (hyperprolactinaemia) or growth hormone levels (acromegaly).
Cách dùng
Should be taken with food. Always take w/ a meal or snack.
Chống chỉ định
Serious peripheral arterial disorders and coronary insufficiency. Concomitant use w/ phenylpropanolamine.
Thận trọng
Patient w/ past or present psychosis. Avoid abrupt withdrawal. Pregnancy and lactation.
Tác dụng không mong muốn
Nausea, vomiting, dry mouth, obstipation, peripheral oedema, sweating, hallucination, anxiety, confusion, nightmares, insomnia, decreased appetite, dyskinesia, somnolence, vertigo, headache, dystonia, myoclonus, orthostatic hypotension, cold extremities, erythromelalgia, palpitation, dyspnoea.
Thông tin tư vấn bệnh nhân
This drug may cause somnolence, if affected, do not drive or operate machinery.
Chỉ số theo dõi
Monitor regularly for development of impulse control disorders.
Quá liều
Symptoms: Severe dopamine-agonistic reactions e.g. nausea, vomiting and vertigo. Management: Metoclopramide oral drops (or domperidone in parkinsonism) may be given as antidote for mild cases. Severe cases may be treated w/ IM sulpiride 100 mg.
Tương tác
Enhanced sedative effect w/ drugs that have CNS depressant effects (e.g. benzodiazepines, antipsychotics). Mutual antagonistic effect w/ antipsychotic neuroleptics (except clozapine). Risk of vasoconstriction and/or hypertensive crisis w/ sympathomimetics (alpha and indirect) and vasoconstrictive ergot alkaloids. Increased risk of neuropsychic disorders w/ anticholinergic antiparkinsonians. Effects may be attenuated by neuroleptics and other dopamine antagonists.
Potentially Fatal: Risk of vasoconstriction and/or hypertensive crises w/ phenylpropanolamine.
Tương tác với thức ăn
Enhanced sedative effect w/ alcohol.
Tác dụng
Mechanism of Action: Lisuride directly stimulates postsynaptic dopamine receptors, thereby improving or eliminating the reduced locomotion, rigor and tremor. It also suppresses the normal production and flow of milk and improves pathological states of the mammary gland.
Absorption: Rapidly and completely absorbed. Time to peak plasma concentration: 1.1-1.3 hr.
Distribution: Widely distributed into the body. Volume of distribution: 2.3 L/kg. Plasma protein binding: 66%.
Metabolism: Undergoes hepatic metabolism, mainly via oxidation pathways including N'-desalkylation of ethyl groups, hydroxylation of the benzene ring, mono-oxygenation and oxidation of double bonds.
Excretion: Via urine, as metabolites. Plasma elimination half-life: 10 hr.
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Lisuride, CID=28864, (accessed on Jan. 22, 2020)

Bảo quản
Store below 30°C. Protect from light.
Phân loại MIMS
Thuốc trị bệnh Parkinson / Các thuốc khác ảnh hưởng sự điều hòa hormon
Phân loại ATC
N02CA07 - lisuride ; Belongs to the class of ergot alkaloids preparations. Used to relieve migraine.
G02CB02 - lisuride ; Belongs to the class of prolactine inhibitors. Used to suppress lactation.
Tài liệu tham khảo
Bayer New Zealand Limited. Dopergin Tablet data sheet 11 April 2013. Medsafe. Accessed 07/04/2016.

Buckingham R (ed). Lisuride Maleate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 07/04/2016.

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