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Analgesia
Adult: Initially 2.5-10 mg every 6-8 hr as required. Titrate dose slowly and according to response. May also be given via IM or SC inj. Not more than twice daily dosing for prolonged use.
Child: 0.7 mg/kg/day in divided doses every 4-6 hr as required, max 10 mg/dose. Dose should be titrated carefully according to individual requirements.
Child: 0.7 mg/kg/day in divided doses every 4-6 hr as required, max 10 mg/dose. Dose should be titrated carefully according to individual requirements.
Oral
Neonatal abstinence syndrome
Child: 100 mcg/kg increased by 50 mcg/kg every 6 hr until symptoms are controlled. Daily dose should be given in 2 divided doses during prolonged use.
Oral
Intractable cough associated with lung cancer
Adult: 1-2 mg every 4-6 hr. Reduce to 12 hrly during prolonged use.
Oral
Opioid dependence
Adult: Initial dose of 20-30 mg as a single dose. Additional doses of 5-10 mg may be used if withdrawal symptoms are not suppressed or if they reappear. Total dose should not exceed 40 mg on the 1st day. Usual stabilising dose: 40 mg daily in single or divided doses. Once patient has stabilised for 2 or 3 days, dosage may be gradually reduced daily or at 2-day intervals. Dosage must be individualised and adjusted to keep withdrawal symptoms at a tolerable level.
Child: Dose should be individualised according to opiate tolerance. After a period of maintenance treatment, withdrawal should be slow, with doses reduced by <10% at a time with 10-14 day intervals between dose reductions.
Child: Dose should be individualised according to opiate tolerance. After a period of maintenance treatment, withdrawal should be slow, with doses reduced by <10% at a time with 10-14 day intervals between dose reductions.