Breast cancer, Prostate cancer, Lymphoma, Liver cancer
Adult: Initially, 14 mg/m2, then repeat every 3 wk. Adjust subsequent dose according to degree of myelosuppression. Debilitated patients or those who had previous chemotherapy: May reduce initial dose to 12 mg/m2. As part of a combination regimen: May reduce initial dose to 10-12 mg/m2.
Adult: 12 mg/m2 by IV infusion over 5-15 min. Initially, dose may be given once every 3 mth provided neutrophil count is >1500 cells/mm3 and LVEF >50%.
Acute myeloid leukaemia
Adult: 12 mg/m2 daily for 5 days to induce remission. Alternatively, 12 mg/m2 for 3 days in combination with cytarabine.