Procainamide


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intravenous
Short-term management of severe or symptomatic arrhythmias, Ventricular arrhythmias
Adult: Dilute in 5% glucose soln and given in doses of 100 mg every 5 min at a rate not exceeding 50 mg/min until arrhythmia has been suppressed or a max of 1 g has been reached. Alternatively admin by continuous infusion of 500-600 mg over 25-30 min with ECG monitoring followed by infusion at a rate of 2-6 mg/min.
Child: Loading dose of 10-12 mg/kg, followed by continuous infusion of 20-75 mcg/kg/min.
Elderly: Dosage reduction or increase in dosing intervals is recommended.

Oral
Short-term management of severe or symptomatic arrhythmias, Ventricular arrhythmias
Adult: 50 mg/kg daily in divided doses every 3-6 hr.
Child: 15-50 mg/kg daily in 4 divided doses.
Elderly: Dosage reduction or increase in dosing intervals is recommended.
Renal Impairment
Dosage reduction or increase in dosing intervals is recommended.
Hepatic Impairment
Dosage reduction is recommended.
Cách dùng
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. May also be taken w/ food or milk to avoid stomach upset.
Chống chỉ định
Heart block, SLE, heart failure, hypotension, myasthenia gravis, digoxin toxicity, lactation.
Thận trọng
Myocardial damage or severe organic heart disease, asthma. Perform regular blood tests. Screen for lupus erythematosus. Serum antinuclear factor should be carried out before and regularly during therapy. Pregnancy, elderly, hepatic and renal impairment. May worsen torsade de pointes. Pre-treatment with digoxin may be necessary if procainamide is used in the treatment of atrial tachycardia. IV admin may cause severe hypotension, thus slow inj and monitoring of ECG and BP are recommended.
Phản ứng phụ
Severe hypotension, ventricular fibrillation and asystole with rapid IV admin. Drug-induced SLE syndrome; blood disorders; fever myocardial depression, heart failure, agranulocytosis after prolonged treatment, psychosis, angioedema, hepatomegaly; skin irritation; hypergammaglobulinaemia; GI disorders; CNS effects.
IM/IV/Parenteral/PO: C
Tương tác
May enhance effects of antihypertensives, other antiarrhythmics, antimuscarinics and neuromuscular-blocking drugs and diminish those of parasympathomimetics. Increased clearance when used with alcohol. Increased plasma concentrations and toxicity of procainamide when used with trimethoprim.
Potentially Fatal: Increased risk of arrhythmias with terfenadine and antipsychotics that prolong QT interval.
Tác dụng
Description: Procainamide directly interferes with depolarization of the cell membrane by blocking the fast inward current of Na into cardiac cells. It slows the rate of change of the depolarization phase of the action potential, moderately prolong the PR, QRS and QT intervals on ECG monitoring. It also has local anesthetic properties.
Pharmacokinetics:
Absorption: Readily and almost completely absorbed.
Distribution: Widely distrbuted and only about 15-20% bound to plasma proteins. Crosses the placenta and passes into the breast milk.
Metabolism: Hydrolysis and acetylation in the liver,
Excretion: Excreted in the urine via active renal secretion. About 30-70% as unchanged drug. Elimination half-life of procainamide is about 2.5-5 hr.
Phân loại MIMS
Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Procainamide từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in