Loading dose: 500 mcg/kg over 1 min; Maintenance: 50 mcg/kg/min for 4 min. If response is satisfactory, continue maintenance infusion. If response is unsatisfactory, give 2nd loading dose of 500 mcg/kg, followed by maintenance infusion of 100 mcg/kg/min for 4 min. If needed, procedure may be repeated 1-2 times (up to max of 3 loading doses), maintenance infusion may be increased by 50 mcg/kg/min each time (max: 200 mcg/kg/min). Maintenance infusion may be continued for up to 24 hr. Maintenance titrated to heart rate or other clinical endpoint. Peri-op HTN &/or tachycardia
Intra-op: Loading dose: 80 mg (approx 1 mg/kg) bolus over 30 sec followed by 150 mcg/kg/min infusion, may be increased to 300 mcg/kg/min if necessary. Post-op: Loading dose: 500 mcg/kg/min over 1 min followed by 4-min infusion of 50 mcg/kg/min. If effect is not observed w/in 5 min, repeat same loading dose & follow w/ a maintenance infusion increased to 100 mcg/kg/min.