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Calquence

Calquence Description

Manufacturer:

AstraZeneca

Distributor:

Zuellig
Full Prescribing Info
Description
CALQUENCE capsules for oral administration contains 100 mg acalabrutinib.
CALQUENCE (acalabrutinib) is an inhibitor of Bruton tyrosine kinase (BTK). The molecular formula for acalabrutinib is C26H23N7O2, and the molecular weight is 465.51. The chemical name is 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl)}-N-(pyridine-2-yl)benzamide.
Acalabrutinib is a white to yellow powder with pH-dependent solubility. It is freely soluble in water at pH values below 3 and practically insoluble at pH values above 6.
Excipients/Inactive Ingredients: silicified microcrystalline cellulose, partially pregelatinized starch, magnesium stearate, and sodium starch glycolate.
Capsule shell: gelatin, titanium dioxide, yellow iron oxide, FD&C Blue 2; imprinted with edible black ink.
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