Anzatax

Anzatax

paclitaxel

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Paclitaxel
Indications/Uses
Primary treatment of ovarian cancer in combination w/ platinum agent. Metastatic ovarian or breast cancer, after failure of standard therapy; non-small cell lung cancer (NSCLC); metastatic breast cancer, in combination w/ trastuzumab, in patients who have tumours that overexpress HER2 at 3+ level & who has not received previous chemotherapy.
Dosage/Direction for Use
Primary treatment of ovarian cancer 175 mg/m2 IV over 3 hr or 135 mg/m2 IV over 24 hr, followed by cisplatin 75 mg/m2 repeated every 3 wk. Metastatic ovarian or breast cancer; primary or secondary treatment of NSCLC Single agent: 175 mg/m2 IV over 3 hr repeated every 3 wk.
Contraindications
Hypersensitivity to paclitaxel, PEG-35 castor oil (Cremophor EL). Severe neutropenia.
Special Precautions
Not to be administered as intracerebral, intrapleural or intraperitoneal inj. Severe hypersensitivity reaction. Premed w/ corticosteroids, antihistamines & H2-receptor antagonist before every treatment cycle. Patients w/ pre-treatment neutrophil count of <1,500 cells/mm3; severe neutropenia (<500 cells/mm3) for ≥7 days during treatment. Serious conduction abnormalities, preexisting neuropathy. Exclude bowel perforation in patients w/ abdominal pain. Renal & hepatic impairment. Pregnancy. Not to be used during lactation. Childn.
Adverse Reactions
Hypotension; anaemia; neutropenia; elevated alkaline phosphatase, AST, ALT; flushing, rash; upper resp tract infection, UTI, sepsis; nausea, vomiting, diarrhoea, mucositis; arthralgia, myalgia; peripheral neuropathy; alopecia. Bradycardia, ECG abnormalities; febrile neutropenia; elevated bilirubin; dyspnoea, hypotension, chest pains, tachycardia.
Drug Interactions
Decreased clearance w/ cisplatin. Inhibited metabolism by ketoconazole & drugs metabolised in the liver eg, erythromycin. Increased doxorubicin plasma levels. Elevated mean serum trough conc of trastuzumab. Higher incidence of arthralgia or myalgia w/ filgrastim.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01CD01 - paclitaxel ; Belongs to the class of plant alkaloids and other natural products, taxanes. Used in the treatment of cancer.
Presentation/Packing
Form
Anzatax inj 100 mg/16.7 mL
Packing/Price
1's
Form
Anzatax inj 150 mg/25 mL
Packing/Price
1's
Form
Anzatax inj 30 mg/5 mL
Packing/Price
1's
Form
Anzatax inj 300 mg/50 mL
Packing/Price
1's
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