Not to be administered as intracerebral, intrapleural or intraperitoneal inj. Severe hypersensitivity reaction. Premed w/ corticosteroids, antihistamines & H2
-receptor antagonist before every treatment cycle. Patients w/ pre-treatment neutrophil count of <1,500 cells/mm3
; severe neutropenia (<500 cells/mm3
) for ≥7 days during treatment. Serious conduction abnormalities, preexisting neuropathy. Exclude bowel perforation in patients w/ abdominal pain. Renal & hepatic impairment. Pregnancy. Not to be used during lactation. Childn.