Anzatax Injection Concentrate is a sterile solution containing 6 mg/mL paclitaxel, 2 mg/mL Anhydrous Citric Acid BP, 527 mg/mL PEG 35 Castor Oil and Ethanol BP.
Paclitaxel is described chemically as (2 S,5 R,7 S,10 R,13 S)-10,20-bis(acetoxy)-2-benzoyloxy-1,7- dihydroxy-9-oxo-5,20-epoxytax-11-en-13-yl (3 S)-3-benzoylamino-3-phenyl D-lactate.
Paclitaxel is an anticancer agent from the taxane class of drugs. It is a white powder with a molecular weight (MW) of 853.9.
Anzatax Injection Concentrate must be diluted prior to intravenous infusion.
It is a clear to pale yellow solution, free of visible particles.
Anzatax Injection Concentrate has a pH of 6 to 7. Paclitaxel is extremely hydrophobic, and is therefore formulated in PEG 35 castor oil and ethanol.