Discontinue use if GI perforation or fistula, acute MI or other clinically significant thromboembolic complication, nephrotic syndrome develops; in patients w/ wound healing complications requiring medical intervention, posterior reversible encephalopathy syndrome; if severe/persistent HTN or hypertensive crisis, osteonecrosis of the jaw occurs. Interrupt, reduce or discontinue use in case of persistent or recurrent significant GI ARs, biochemical laboratory test abnormalities. Not to be administered in patients who have or at risk for severe haemorrhage. Aneurysms &/or artery dissections; palmar-plantar erythrodysaesthesia syndrome (PPES); history of QT interval prolongation, relevant pre-existing cardiac disease, bradycardia or electrolyte disturbances. Regularly monitor platelet levels, urine protein & periodic monitoring w/ on-treatment ECGs & electrolytes (serum Ca, K & Mg) during treatment. Perform LFTs prior to initiation & monitor liver enzymes during treatment. Monitor for signs & symptoms of hepatic encephalopathy, thyroid dysfunction. Perform oral exam prior to initiation & ensure good oral practice during treatment. Discontinue use at least 28 days prior to scheduled surgery including dental surgery or invasive dental procedures. Not to be used in patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Avoid chronic use w/ strong CYP3A4 inducers. Concomitant use w/ CYP3A4 inhibitors; bisphosphonates; antiarrhythmics; P-gp substrate eg, fexofenadine, aliskiren, ambrisentan, dabigatran etexilate, digoxin, colchicine, maraviroc, posaconazole, ranolazine, saxagliptin, sitagliptin, talinolol, tolvaptan; MRP2 inhibitors eg, cyclosporine, efavirenz, emtricitabine. May affect ability to drive & use machines. Not recommended in severe hepatic (Child-Pugh C) & renal impairment. Moderate hepatic & mild to moderate renal impairment. May impair male & female fertility. Women of childbearing potential & male partners should use effective contraception during & at least 4 mth after last dose. Not to be used during pregnancy & lactation. Childn & adolescents <18 yr.